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The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

In other brain regions, astrocytes sense diverse neurotransmitters and neuromodulators and, in turn,

Crinetics hires people with big brains and small egos.”

Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic

mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal and blood-brain

highly expressed in CA1 hippocampal neurons, selectively reduces CaV 3.2 and CaV 3.3 currents GPCR Binders

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

treatment of neuropathic pain, a debilitating condition caused by damage to the nerves outside of the brain

accumbens shell and structures in the prefrontal cortex and amygdala, which were previously linked to the brain

immune system, including neutrophils, monocytes, and macrophages in the periphery and microglia in the brain

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling GPCR Binders

GPCR Binders, Drugs, and more Rational design of highly stabilized and selective adrenomedullin analogs

GPCR Binders, Drugs, and more In silico identification of a biarylamine acting as agonist at human β3

New Insights into MRP3 Transporter Function "Glioblastoma is the most common and aggressive primary brain

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

GPCR Binders, Drugs, and more Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection

GnIH) system in the European sea bass, Dicentrarchus labrax, which exerted an inhibitory action on the brain-pituitary-gonadal

GPCR Binders, Drugs, and more Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium

We found that Adgra1 is highly and exclusively expressed in the brain, suggesting that Adgra1 may be

However, the pharmacokinetic properties of DOI differed among sexes - brain and plasma concentrations

GPCR Binders, Drugs, and more Persistent challenges in the development of an mGlu7 PAM in vivo tool compound

and mGluR2-mediated increase in pathogenic tau but also show that β-arrestin1 levels are increased in brains

Recordings in brain slices have shown that co-activation using saturating concentrations of agonists

Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle GPCR Binders

glycosaminoglycans in GPCR signaling G protein-coupled receptor-mediated autophagy in health and disease GPCR Binders

space, limiting their ability to identify truly novel chemotypes”(Thomas, Smith, O’Boyle, de Graaf & Bender

GPCR Binders, Drugs, and more Molecular Characterization of Two Wamide Neuropeptide Signaling Systems

as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells GPCR Binders