Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy

patients with WHIM syndrome Bristol Myers Squibb’s Investigational LPA1 Antagonist Reduces the Rate of Lung

Hay, Lukas Grätz, and more. Check out some of the latest GPCR discoveries below!

DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits

First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India

and Target Engagement Novo Nordisk's GLP-1 for Type II diabetes approved for first-line treatment The Lundbeck

analyses, have indicated that OR genes are also expressed in non-olfactory tissues including the testis, lung In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and

Transcriptome profiling of male and female Ascaris lumbricoides reproductive tissues.

Knockdown of GPR125 as well as that of Dlg1 results in formation of aberrant cysts with multiple lumens

show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

Although GnIH1 and GnIH2 had no effect on basal CRE-luc activity, they significantly decreased forskolin-elicited CRE-luc activity in COS-7 cells transfected with their cognate receptor GnIHR. Moreover, an evident increase in SRE-luc activity was noticed when COS-7 cells expressing GnIHR were Notably, GnIH2 antagonized Kiss2-evoked CRE-luc activity in COS-7 cells expressing GnIHR and Kiss2 receptor However, GnIH peptides did not alter NFAT-RE-luc activity and ERK phosphorylation levels.

be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung

Pulmonary Fibrosis "Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung We demonstrate that OGR1 protein expression is significantly reduced in lung tissue from patients with

immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung

Gq/11 signaling of chimeric receptors was analyzed using luciferase-based reporter gene (NFAT) assays

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

cardiovascular diseases, renal diseases, autoimmune diseases such as systemic sclerosis or systemic lupus

Luisa Salter-Cid , Dr. Omar Nadeem and Dr.

We previously demonstrated rescue of cell surface expression of luteinizing hormone receptor mutants

November 2021 "Cambridge’s Japanese-owned life sciences company Sosei Heptares has clinched a lucrative