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Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells. GPCRs in Immunology and Oncology The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer Structure pulls off rare IPO, raising $161M 3-drug combo leads to 'unprecedented' response in pancreatic cancer

receptors (aGPCRs)-a major family of GPCRs-play critical roles in the regulation of tissue development and cancer

For example, chemotherapy, a powerful standard approach to kill fast-growing cancer cells, has the drawback

GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.

Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer

also opens doors for exploring the roles of these receptors in various pathological states, including cancer

scientists uncover “plant-like” behavior in important human cell regulator, opening up a new drug target for cancer spinal cord injury GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration

mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations

Nominated for Prestigious Prix Galien USA ‘Best Startup’ Award: Pioneering GPCR-Driven Immunotherapies in Cancer future directions Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer

in the chemokine system can also contribute to various diseases, such as inflammatory conditions and cancer

from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers

signaling pathway, which is involved in embryonic development and is implicated in various types of cancer

Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer

GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer

For instance, aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer

GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled

correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer

intertwining roles of caveolin, oxytocin receptor, and the associated signalling pathways in prostate cancer

reinforces consistent reduction in risk of recurrence across key subgroups of patients with early breast cancer

GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets for ovarian cancer

GPCR Events, Meetings, and Webinars NEW AACR 2023 - American Association for Cancer Research (April 14

kidney disease GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer

protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer

and Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer

back again: the lysophosphatidic acid-CCN axis in signal transduction NPFF stimulates human ovarian cancer