therapeutically exploit GPCRs (Physiology’s ‘Swiss Army Knife’) vast repertoire of ways to control cell Take action immediately to join our esteemed learning community! in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell by sphingosine kinase-1 GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract Intracellular

Let's explore the newest developments in GPCR research and community news together! Monserrat Avila-Zozaya , our incredible contributor, for her fantastic article on Profiling Immune Cell Act now to become a part of our prestigious learning community! Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell

understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. on key signaling events involved in the activation and differentiation of these cells. We also review the hierarchy of signaling events driving the fibrotic response and the communications between fibroblasts and other cells in the heart.

Front Cell Dev Biol, 2021. 9: p. 611443. 3.      Cell, 2020. 182(3): p. 770-785.e16. 4.      Galés, C., et al., Real-time monitoring of receptor and G-protein interactions in living cells.  Nature Communications, 2016. 7(1): p. 12178. 11.    Strungs, E.G., L.M. Luttrell, and M.H. Goyet, E., et al., Fast and high resolution single-cell BRET imaging. 

of the Year at the Citeline Japan Awards 2024 GPCR therapies: Eight promising biotechs hacking the cell Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Approaches Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells ) The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells

express multiple ORs, tumor cells associated with the nervous system express a single OR gene type ( proliferation via activation by β-ionone which initiates prostate cancer cell cycle arrest (Jones S. In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and identified ligands being often synthetic compounds, there has been a growing interest from the scientific community The chimeric antigen receptor T cell therapy could also be a way to target tumor cells expressing ectopic

., for their study on Cell swelling enhances ligand-driven β-adrenergic signaling ✨ Reserve Your seat Carterra Ultra™ ushers in a new frontier in fragment and small molecule drug discovery Is the pharma community This technique for studying cell receptors could have sweeping implications for drug development DeepCure , 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based plate homeostasis through IHH Signaling GPCR Activation and Signaling Illuminating GPCR trafficking Cell

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the , and CCR5 switch purely to scavenging (D'Amico G. et al. 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes in the cell motility machinery with

GPCR Ecosystem and our community. The classes will be online Thursdays from 10 am EST. for disease therapy GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic profiling highlights cell Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology Optical Control of Cell-Surface

Join the global GPCR community and share your research—submit your abstract using this form. Oncology and Immunology Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 laboratory and point-of-use settings Quantitative proteomics reveals CLR interactome in primary human cells Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors TOR signaling

GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control

., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012 Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 This well-established, distinctive pattern of cell expression has been directly challenged by a publication and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells

If you want to share your work with our community, please don’t hesitate to fill out this form. neurological and psychiatric disorders: An in silico approach Opioid modulation of prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation progression in MCF-7 cells Methods & Updates in GPCR Research Cryo-electron microscopy for GPCR research Illinois Septerna divulges new TSHR antagonists for hyperthyroidism Unlocking the Secrets of Cellular Communication

Act Now and Become a Valued Member of our Learning Community! Agonist for the Treatment of Hypoparathyroidism Confo Therapeutics Announces Publication in Nature Communications in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell research position Adhesion GPCRs The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell regulate a wide spectrum of endocrine tumors G protein coupled receptor transcripts in human immune cells

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell

Congratulations to the GPCR Therapeutics team for their publication on improving hematopoietic stem cell Activation and Signaling The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function GPCR Binders, Drugs, and more GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol Discovery

al. for their fantastic work on Germline mutations in a G protein identify signaling cross-talk in T cells Take Action Now and Join our Community of Learners! Biosciences, INC as a Preferred Supplier at Prendio Crinetics Pharmaceuticals announces executive departure Call in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell GPCR Activation and Signaling Germline mutations in a G protein identify signaling cross-talk in T cells

Smith for their research on β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells If you want to showcase your research, you can submit a poster presentation to our community, take advantage of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells Announces Publication in PNAS Using Cutting Edge Spectroscopy to Detect GPCR Heteromers on Live Cancer Cells

Exciting event listings to keep you on your toes  Direct line to all the cool cats in the GPCR community This transition will enable us to invest in higher-quality content and resources, ensuring our community Therapeutics, Inc. has received Orphan Drug Designation (ODD) from the FDA for its hematopoietic stem cell 2024 | 16th Annual PEGS Europe   NEW November 25 - 26, 2024 | 6th International Conference on Stem Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell

ERK signaling, tightly regulated through feedback mechanisms and spatial localisation within the cell Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression. Cells, 10(10), 2509. Volmat, V., & Pouysségur, J. (2001). Biology of the Cell, 93(1‐2), 71-79. Wei, H., Ahn, S., Shenoy, S. K., Karnik, S.

We selected the adenosine receptor 2B (A2BAR), specifically expressed in cancer cell lines compared with stromal cells, to explore the use of fluorescent ligands that can be used for target visualization. Fluorescent probes allowed semi-quantitative receptor mapping in living cells and validated the specific expression of A2BAR in CRC cell lines. a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor cell

RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate immune cell activation and cytokine production. to T cell activation[6]. Cell, 1997. 89(2): p. 251-61. https://pubmed.ncbi.nlm.nih.gov/9108480/ 2. Cell, 2021. 184(4): p. 931-942.e18. https://pubmed.ncbi.nlm.nih.gov/33571431/ 6.

Join the global GPCR community to present your research—submit your abstract using this form. uncover GPR183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells Scientist Senior Research Associate/Associate Scientist, Protein Science Post-Doctoral Fellow—Pharmacology/Cell

as in human melanoma cells either expressing (A7) or lacking (M2) FLNA. First, we observed the formation of endogenous SST5 homo-dimers in GH3, A7, and M2 cells. SST2 and SST5 can also form endogenous hetero-dimers in these cells. robust receptor internalization at shorter times than in A7 cells. In conclusion, we demonstrated that in GH3 cells SST2 and SST5 can form both homo- and hetero-dimers

product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell Specifically, previous research has identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune cell inflammatory state, antimicrobial killing capacity, and metabolism of C3a has been relegated to the serum; however, recent studies have provided evidence that various cell Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific

Take action immediately to join our esteemed learning community! Hypoparathyroidism World first: Australian scientists uncover “plant-like” behavior in important human cell regulator, opening up a new drug target for cancer, other diseases Call for GPCR Papers Deadline: Nov in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell Therapy Methods & Updates in GPCR Research Protocol for detecting endogenous GPCR activity in primary cell

2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living Cells "Conformational biosensors to monitor the activation state of G protein-coupled (H3R) biosensor that allowed the detection of both (partial) agonism and inverse agonism on living cells In the current study, we have further characterized this H3R biosensor on intact cells by monitoring binding assays that in addition can also detect ligand efficacies with comparable values as the intact cell

this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement in cell THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from both the THP-1 cell line and human peripheral blood monocytes."