“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to

and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu, Zhao namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao activation will pave the way for significant advancements in the development of therapeutics for a wide range