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59 items found for "Chao-Fu Wang"

  • From DNA day to GPCR genomics

    The completion of the Human Genome Project revealed that GPCR genes in the human genome range from approximately

  • Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery

    “ A substitution of one amino acid by another in a protein can have effects ranging from negligible to

  • Structural landscape of the Chemokine Receptor system

    and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu, Zhao namely CCL15L (residues 26-92) and CCL15M (residues 27-92), while the third structure lacks a ligand (Shao conformational change of Y2917.43 tilted toward TM2, a model supported by mutagenesis experiments (Shao activation will pave the way for significant advancements in the development of therapeutics for a wide range

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