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schedule Dopamine-Mediated Motor Recovery after Ischemic Stroke Date & Time Friday, November 3rd / 8:30 AM Abstract development of new therapeutic interventions for the alleviation of L-DOPA-induced dyskinesia in Parkinson’s Disease

ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Published date July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation

Join me and learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol

and pharmacology can provide new opportunities to improve our understanding of human physiology and disease ML/AI can be powerful for identifying abstract patterns within large data where traditional methods would

peptides differentially regulate signaling by the receptors CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines are often elevated in disease settings, where the largest group of CC-chemokines

against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Published date September 21, 2024 Abstract Colorectal cancer (CRC) is a prevalent malignant tumor worldwide, leading to significant morbidity and disease

promotes fibroblast-to-myofibroblast transition in organ fibrosis progression Published date July 22, 2024 Abstract deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts in response to chronic

and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract humoral immunity and discuss the potential of the COMMD3/8 complex as a therapeutic target for autoimmune diseases

Much of his work is based on GPCR signaling in the context to cardiovascular diseases.

promoting an alternative-like polarization during bacterial infection Published date February 13, 2024 Abstract expressed NPFF, these findings could have broad implications in various infectious and inflammatory diseases

from RA patients is involved in leukocyte chemotaxis to the synovium Published date November 1, 2022 Abstract Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response

dose-response for asbestos cancer risk implied by new inflammation-mutation model Published date August 1, 2023 Abstract implications of this theory are discussed in relation to mesothelioma and lung cancer associated with chronic

Structure and Function of Typical Chemokine Receptors Date & Time Saturday, November 4th / 11:00 AM Abstract Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing

targeting of GPCR-independent noncanonical G-protein signaling in cancer Published date April 25, 2023 Abstract small molecules can selectively disable noncanonical mechanisms of G-protein activation dysregulated in disease

of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma Published date August 22, 2024 Abstract Despite advances in the treatment, many patients experience disease relapse or become refractory to treatment

cell adhesion molecule NEGR1 affects mGluR5 cell signalling Date & Time Friday, November 3rd / 1:30 PM Abstract were shown to be very effective to rescue the cell death observed in a mouse model of Huntington’s disease

My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases She is currently working to understand the signaling and degradation of GPCRs in disease states to help

Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Diseases

and clinical pharmacology as scientist or PI in neonatal lupus, Cardiomyopathy, hypertension, chagas disease

ESCRT-dependent exosome biogenesis and promotes cancer metastasis Published date February 27, 2023 Abstract Exosomes transport a variety of macromolecules and modulate intercellular communication in physiology and disease

Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity Published date October 14, 2024 Abstract essential in regulating GPCR signaling, and most members are implicated as critical nodes in human diseases

agonists of angiotensin II type 2 receptor may prevent colorectal cancer Published date June 24, 2024 Abstract "Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease with poor prognosis.

Y5 reduces hypoxic breast cancer migration, proliferation, and signaling Published date May 30, 2023 Abstract Conclusions: Antagonizing the NPYRs has been implicated as a treatment for a wide variety of diseases

at the University of Bonn, Germany, working initially on the role of prostaglandin receptor EP4 in chronic

his research on biased agonism at GPCRs with a particular focus on the treatment of cardiovascular disease

In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the

tiny antenna-shaped structure at the cell surface with critical links to development, physiology, and disease