< GPCR News < GPCRs in Oncology and Immunology Comparison of infectious complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen (BCMA) -directed therapies are highly active for multiple myeloma, but infections are emerging as a major challenge Authors Karthik Nath, Tala Shekarkhand, David Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Noriko GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

< GPCR News < GPCRs in Oncology and Immunology Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus Published date May 13, 2023 Abstract "The adipokine chemerin is the Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g This may help to develop more potent ligands for the treatment of inflammatory related diseases." GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

< GPCR News < GPCRs in Oncology and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration Published date June 25, 2023 Abstract "Bombesin receptor The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations Verification experiments demonstrated that downregulation of the Hippo signaling pathway caused by BRS3 Our data collectively demonstrate that BRS3 activation contributes to cell migration through downregulation

dysbiosis in IBD patients: Potential role of GPR109A in macrophages Published date September 2, 2024 Abstract "Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by disrupted immune function. The role of GPR109A was studied in depth and increased expression of this receptor was detected in epithelial Mira, Dolores Ortiz-Masiá, María Dolores Barrachina, Jesús Cosín-Roger Tags GPR109A , IBD , Metabolite-sensing

< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10 Published date January 29, 2024 Abstract "Growth-blocking SRP gene expression has been also demonstrated to be enhanced by GBP, indicating that both cytokines Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Khaled Abdelrahman About Dr. Khaled Abdelrahman Dr. He joined the laboratory of Dr. In 2015, He joined Dr. discovery in the area of neurodegenerative diseases. Dr. Khaled Abdelrahman on the web Twitter PubMed Google Scholar Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Silvia Sposini About Dr. I moved to London as a short experience (3 months) during my MSc but I ended up staying for a full year During my time in London I investigated regulatory mechanisms of GPCR action, namely dimerization and membrane trafficking, in Dr Aylin Hanyaloglu 's lab at Imperial College London. Silvia Sposini on the web Bordeaux Neurocampus LinkedIn ResearchGate X (Twitter) Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Gregory Tall About Dr. Gregory Tall " Dr. In 2000, Dr. In 2007, Dr. Dr. Dr.

and Immunology Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21, 2024 Abstract "Colorectal cancer (CRC G protein signaling (RGS) protein family modulators play essential role within regulating downstream disease-specific survival (DSS) and disease-free survival (DFS) compared to those with low RGS16 expression GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

Dr. GPCR Podcast << Back to podcast list Brian Shoichet About Dr. Dr. Brian Shoichet on the web Google Scholar Shoichet Lab Twitter Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Timo De Groof About Dr. Timo De Groof Dr. diseases and oncology. Dr. Martine Smit . During his Ph.D., Timo, together with Dr. Raimond Heukers , developed a nanobody platform within the research group and used this platform to develop Dr. Timo De Groof on the web LinkedIn Researchgate Twitter Medical Imaging Group Google Scholar Dr.

Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Published date July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s. GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

SEA Domain and Its Impact on GAIN Domain Autoproteolysis Bill Huang Tethered Agonist Dependent ADGRL3 Ductal carcinomas are increasingly diagnosed but identifying which will progress to invasive disease remains difficult highlighting an urgent need for new biomarkers that distinguish ductal carcinomas on A recent study demonstrated that GPR56 in the glomerular endothelial cells promoted diabetic kidney disease To determine the physiological role of GPR56 in the collecting duct, we generated a collecting duct-specific

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic potential , malignant melanoma is one of the deadliest skin cancers. GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

Dr. As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and Berchiche is the founder of Dr. The mission of Dr. Dr.

measures the missense tolerance ratio (MTR) using a three-dimensional (3D) structure (3DMTR). ( P < 0.05) in each dataset. were selected to define the functional phenotype. In downstream cAMP measurement, tolerant RGS14-D137Y and RGS10-S64T and intolerant RGS10-K89M resulted We used the novel bioinformatics tool three-dimensional missense tolerance ratio (3DMTR) to define regions

< GPCR News < GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model Published date August 1, 2023 Abstract "Alterations in complex In contrast, a linear no-threshold (LNT) dose-response relationship is expected for damage that accumulates in proportion to dose, as hypothesized for increased risk of cancer in relation to genotoxic dose according GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Graciela Pineyro About this episode: Dr. Graciela Pineyro is a professor of pharmacology at the department of pharmacology and physiology of the She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing Dr. Graciela Pineyro on the web Dr. Graciela Pineyro on LinkedIn Dr. Graciela Pineyro - University of Montreal Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Bryan Roth About this episode Dr. Bryan Roth is the Michael Hooker Distinguished Professor of Pharmacology at the University of North Carolina He was determined to work on psychiatric disorders and persevered even when he was told several times Dr. Better Psychiatric Medications LinkedIn Bryan Roth on Twitter Roth Lab on Twitter Google Scholar Pubmed Dr

Dr. GPCR Podcast << Back to podcast list Dr. Richard Premont About Dr. Richard Premont "Dr. In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke University. 2018 studying GPCRs and their signaling pathways in the liver and in liver disease. Dr. Richard Premont on the web Google Scholar LinkedIn Dr.

"Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells (DCs) In this research, our team allocated GPR97 depletion (GPR97-/-), GPR97 conditional depletion on dendritic In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected differentiation. activation in DCs.

GPCR News < GPCRs in Oncology and Immunology Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy Published date October 4, 2024 Abstract "Olfactory receptors (ORs) are a class of G protein-coupled receptors (GPCR) widely distributed in olfactory sensory neurons and various non-olfactory GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr. Follow the Dr. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

< GPCR News < GPCRs in Oncology and Immunology Molecular docking and dynamics simulation studies uncover host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus Published date Despite its significance in this industry, the biological knowledge of its pathogenesis remains unclear and dynamics (MD) simulation. GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.

Dr. GPCR Podcast << Back to podcast list Dr. Stuart Maudsley About Dr. Following his Ph.D., Dr. novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles. Dr. Reddit Dr.

durable responses. Here, we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct These include EP2, EP4, A2AR, β1AR and β2AR, all of which promote T cell dysfunction. We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8 These data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program

Dr. GPCR Podcast << Back to podcast list Dr. Graciela Pineyro About this episode Dr. , trafficking, and their ability to activate different signaling pathways and signaling bias. Today, Graciela and her team’s efforts are directed towards the characterization of the pharmacological Dr. Graciela Pineyro on the web Dr. Graciela Pineyro on LinkedIn Dr. Graciela Pineyro - University of Montreal Dr.

and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic cancer. To date, many small-molecule CXCR2 antagonists have entered clinical trials, showing favorable safety pulmonary disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease. GPCR Create an account and get our contributors articles in your inbox Subscribe to the Dr.