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231 items found for "David Reiner-Link"
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
for the analysis of gene expression by RT-PCR or protein expression by western blotting and enzyme-linked
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell line and the results showed that GPR50 was significantly up-regulated in HCC patients and CBRH-7919 cell line Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
function in human non-ischaemic heart failure Published date April 1, 2023 Abstract " Aims: A causal link
- Ep 53 with Dr. Timo De Groof
Timo hopes to combine his previous GPCR experience with his current focus to set up his own research line Timo De Groof on the web LinkedIn Researchgate Twitter Medical Imaging Group Google Scholar Dr.
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines QRT-PCR was used to validate the expression of PAXIP1-AS1 in OC cell lines. PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line.
- Ep 142 with Dr Claudia Stäubert
Claudia Stäubert on the web Stäubert Lab, Rudolf Schönheimer Institute of Biochemistry Leipzig LinkedIn They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into
- GPCR Retreat 2023 - Part I
who translate important GPCR research into novel therapies for patients. " Irfan Dhanidina on the web LinkedIn allosteric sites and exert pathway-specific effects on receptor signaling, they are exciting tools for linking Lauren Slosky on the web University of Minnesota Department Page Twitter LinkedIn Google Scholar PubMed
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- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
hypoxia on migration, proliferation, invasion, and signaling in 2D and 3D models of breast cancer cell lines There were some discrepancies in the responses of each cell line to the isoform-specific antagonists
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- Ep 145 with Dr John Janetzko
spectrometry and protein crystallography, which shaped my interest in understanding how protein dynamics are linked Outside of the lab, I am an avid bike racer, an occasional cycling coach, and I enjoy spending time with Janetzko on the web Stanford University Stanford Medicine Google Scholar Personal Website ResearchGate LinkedIn
- LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer cell line LPA1 heteromers on CXCL12-induced signaling and cell migration have been evidenced across various cell lines
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas National Institutes of Health, Rockville, MD, USA" About Bill Huang "Researcher" Bill Huang on the web LinkedIn Júlia Rosell on the web LinkedIn Endocytic Cues Determine the Signaling Profile of Adhesion GPCR ADGRL1 Sheila Ribalta-Mena " Cell Biology PhD student " Sheila Ribalta-Mena on the web CINVESTAV ResearchGate LinkedIn Mariam Melkumyan on the web LinkedIn Google Scholar < Previous Session Next Session >
- Session II | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial unique junction arrangements where aGPCRs are mainly unexplored. " Monserrat Avila Zozaya on the web LinkedIn To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines
- Ep 154 with Dr Badr Sokrat
Badr Sokrat on the web PubMed ResearchGate LinkedIn Dr. shared his learning process and early tasks at Michelle’s lab, which involved creating stable cell lines
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes
Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression.
- Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation
Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML cell lines
- Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration
The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
Here, we show that HRH1 is widely expressed in various cancer cell lines and cancer tissues and that
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell lines
- The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication
Cell lines expressing EBI2 were established by transduction with HIV vectors.
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
Hern Wang Cheng , Arjandas Mahadev , Matthew Chau Hsien Ng , Michaela Su-Fern Seng , Prasad Iyer , Pei Ling
- Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells
- The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells
We probed CXCR4 and β2AR homo- and heteromultimerization in model cell lines and found that CXCR4 assembles
- Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer cell lines