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show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet

Although GnIH1 and GnIH2 had no effect on basal CRE-luc activity, they significantly decreased forskolin-elicited CRE-luc activity in COS-7 cells transfected with their cognate receptor GnIHR. Moreover, an evident increase in SRE-luc activity was noticed when COS-7 cells expressing GnIHR were Notably, GnIH2 antagonized Kiss2-evoked CRE-luc activity in COS-7 cells expressing GnIHR and Kiss2 receptor However, GnIH peptides did not alter NFAT-RE-luc activity and ERK phosphorylation levels.

immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung

Pulmonary Fibrosis "Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung We demonstrate that OGR1 protein expression is significantly reduced in lung tissue from patients with

to be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung

Gq/11 signaling of chimeric receptors was analyzed using luciferase-based reporter gene (NFAT) assays

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

cardiovascular diseases, renal diseases, autoimmune diseases such as systemic sclerosis or systemic lupus

Luisa Salter-Cid, Dr. Omar Nadeem and Dr.

We previously demonstrated rescue of cell surface expression of luteinizing hormone receptor mutants

November 2021 "Cambridge’s Japanese-owned life sciences company Sosei Heptares has clinched a lucrative