In this study, we examined the androgen-independent human prostatic cancer cell line PC3 and find the

Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1

British Columbia Read More Friday, November 3rd / 2:10 PM Genetic Deletion of Atypical VGLUT3 Rescues Huntington

form trusting partnerships, grow, and thrive together to accelerate GPCR drug discovery and improve human

A second area of interest has been the elucidation of the molecular basis for a rare autosomal human

This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

genetic risk factors implicated in schizophrenia by large whole-genome association studies (GWAS) in humans

In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers of hundreds

Published date May 30, 2023 Abstract "Background: Neuropeptide Y (NPY) is an abundant neurohormone in human In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization

mutations found in patient samples derived from the Genomic Data Commons and compared it to the natural human

extends to the development of novel screening approaches to identify pharmacological modulators of human

My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites During my post-doctoral research, I was part of a study that identified the receptors of a novel human My long-term plan is to conduct research in the field of receptor biology, with a focus on GPCRs. serve as targets for more than one-third of all prescribed drugs currently used in the treatment of human

various non-olfactory tissues, serving significant physiological and pathological functions in the human the specific molecular actions and signaling pathways of olfactory receptors in the development of human

Receptors that Regulate the Release of Superoxide Anions Published date July 26, 2024 Abstract "In human Authors Claes Dahlgren, Huamei Forsman, Martina Sundqvist, Lena Björkman, Jonas Mårtensson Tags GPCR

I am also affiliated with György Keserű's group at the RCNS in Hungary. I lived in Denmark, Poland, now I live in Hungary. I am married, I have two daughters.

Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions in humans

From 2002-2006 he was a Howard Hughes Post-Doctoral Fellow at the University of Washington in Seattle families of growth factors and their signaling mechanisms in development, adult tissue homeostasis, and human

Since my undergraduate studies, I have been engaged in researching molecular mechanisms that govern human

., certain asbestos) fibers in humans and experimental animals are thought to involve modes of action

interactions play a key role in human health. Small-molecules that offer a functional readout of microbe-microbe-human relationship are of great interest G protein-coupled receptors (GPCRs) and modulate a range of human physiological functions, offering a mechanistic insight into the microbe-human interaction. Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers of hundreds

From that point on, Paul was hooked and has since studied receptor function in human physiology, receptor animal models, and as he puts it has now he’s "gone full circle" back to studying GPCRs important in human

Eddy began learning and investigating human GPCRs while training in the laboratories of Professors Raymond

Authors Miao Guo , Yan Zhang , Lehao Wu , Ye Sheng , Jiaqi Zhao , Zeyuan Wang , Huiyu Wang , Lu Zhang , Hua Xiao Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News

Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to Results: GPR81 was upregulated in multiple human cancer types and further upregulated by extracellular

platform to develop nanobodies targeting viral G protein-coupled receptors with a special focus on the human

During my Ph.D. at the International Max Planck Research School “The Leipzig School of Human Origins” Claudia discussed developing an ecosystem for the GPCR University, with the goal of providing a central hub