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86 items found for "Dongbo Bu"
- 📰 GPCR Weekly News, February 6 to 12, 2023
SLAS 2023 B Building Biology in 3D Symposium. GPCR Jobs Director, Business Development & Strategy CADD and Informatics Head or Team Lead (depending
- 📰 GPCR Weekly News, January 23 to 29, 2023
SLAS 2023 Building Biology in 3D Symposium.
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
There is a great deal of scientific and business interest in solving this problem, and the last two years
- 📰 GPCR Weekly News, January 16 to 22, 2023
SLAS 2023 Building Biology in 3D Symposium.
- 📰 GPCR Weekly News - January 9 to 15, 2023
SLAS 2023 Building Biology in 3D Symposium.
- Odorant receptors – a bit of smell for drug discovery
In the immune system ORs are expressed in different blood cells where aroma compounds from butter, known In the respiratory system, the activation of ORs by amyl butyrate and bourgeonal, OR2AG1 and OR1D2 agonists sandalore-activated receptor OR2AT4 shown to promote human keratinocyte proliferation and migration (Busse
- 📰 GPCR Weekly News
TMP-301 for Treatment of Alcohol and Substance Use Disorders AbbVie recruits a GPCR team in Oxford, buying
- Ode to GPCRs
The 2004 Nobel Prize in Physiology or Medicine went to Richard Axel and Linda Brown Buck for their work Buck - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/2004/press-release/. 59. Buck – Facts - NobelPrize.org. https://www.nobelprize.org/prizes/medicine/2004/buck/facts/. 60.
- The Gluopsins: Opsins without the Retinal Binding Lysine
To find such opsins, we built an automatic pipeline for reconstructing a large-scale opsin phylogeny. The gluopsins are mainly dragonfly and butterfly opsins, closely related to the RGR-opsins and the retinochromes
- Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair
Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social burden epinephrine) and aldosterone elevations are among the salient alterations that confer significant hormonal burden
- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
increasing prevalence of obesity and type 2 diabetes (T2DM) is provoking an important socioeconomic burden
- Comparative study of neuropeptide signaling systems in Hemiptera
Commercial grapevines worldwide are plagued by the bug Daktulosphaira vitifoliae (Hemiptera: Sternorrhyncha
- Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
Our results build a strong foundation for further improvement of our approach by rationalizing the kinetics
- Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
in Hepatocellular Carcinoma "Hepatocellular carcinoma (HCC) is at the forefront of the global cancer burden
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
Recent studies revealed butyrate and secondary bile acids, produced by the intestinal microbiome, potentiate RNA sequencing of intestinal epithelial cells responding to butyrate and secondary bile acids in combination
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
pCIB > pCIBm in additive ways suppressed collagen- and GPVI-dependent platelet activation, thrombus buildup
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
protein-dependent signaling via twin Cysteine-rich domains linked to transmembrane heptahelical (HH) bundles However, the nature of interactions between VFT units and HH bundles, and the impacts of heterozygous assessed for Ca2+o -stimulated Ca2+i mobilization using mutations in either the VFT domains and/or HH bundle In contrast, a single WT HH bundle was insufficient for maximal signaling and there was no functional
- Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
AVPR1A, or both significantly reduced CRPC tumor growth as well as decreased on-target markers of tumor burden
- Meet Peter McNamara, Ph.D., Tectonic’s SVP, Head of Research
We’re glad to have Peter's dedication, experience, and passion in building innovative therapeutics."
- Addex Therapeutics To Release Full-Year 2021 Financial Results And Host Conference Call On March 10
Tim Dyer, CEO, Roger Mills, CMO and Robert Lütjens, Head of Discovery Biology, will provide a business
- Inversago Pharma Completes Phase 1 Clinical Trial on First-in-Class, Peripheral CB1 Blocker and...
in the launch of Phase 2 clinical development Metabolic disorders are a global epidemic1 MONTREAL--(BUSINESS
- Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in Schizophrenia "BOSTON--(BUSINESS
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
A dataset consisting of β3 -AR agonists was prepared to build and validate the pharmacophore models.
- X4 slashes pipeline, lays off staff just three weeks after netting a $55M PIPE
pulled together a $55 million PIPE and amended a loan facility with Hercules Capital to reduce cash burn
- Design Pharmaceuticals Closes $5 Million Pre-series A Round to Accelerate Commercialization of ...
The proceeds will be used to further build the company’s discovery platform and operations.
- Dr. Juan José Fung - Dr. GPCR Podcast
https://buff.ly/32fzGbO #gpcr #drgpcr #podcast
- TeachOpenCADD - A teaching platform for computer-aided drug design
source programming packages for cheminformatics and structural bioinformatics are powerful tools to build
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
, the New Company Launches with $30M in Initial Financing Provided by 5AM and Frazier – Pipeline is Built