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Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications

embody the multifaceted nature of GPCRs, showcasing their complexity, versatility, and potential for therapeutic

The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic

Institute of Medical Research, Deputy Director of the Australian Research Council Centre for Personalised Therapeutics

We hope our research will aid in the development of new therapeutic interventions for the alleviation

regulation, discuss its target proteins and mechanisms, and conjecture a rationale for developing ITA-based therapeutics

He is also an Associate Leader of the Experimental Therapeutics and Metabolism Program and the Director

Meanwhile, P2Y12R inhibitors can inhibit this effect, suggesting that P2Y12R may be a potential therapeutic

pro-carcinogenic effect of GPR37 in primary CRC and suggest that targeting GPR37 could be a potential therapeutic

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

clinical stage company developing next generation immunotherapies, and member of the SAB of Domain Therapeutics

signaling in the context of humoral immunity and discuss the potential of the COMMD3/8 complex as a therapeutic

What makes each drug type unique to therapeutic pharmacology? 3.

nanobodies as research tools, to investigate different GPCR conformations, while also focusing on their therapeutic

Brian Collier in the Department of Pharmacology and Therapeutics at McGill University (1994).

oncogenic role of GPR87 in various human malignancies, presenting it as a potential novel target site for therapeutic

of different components in AC-related signaling could potentially lead to the development of novel therapeutic

identification, polypharmacology, and effective personalized medicine approaches to achieve better therapeutic

protein-coupled receptors (GPCRs) regulate motivated behavior and how these receptors can be targeted for therapeutic distinct signaling pathways with their physiological effects and may serve as the basis for more selective therapeutics

mechanisms of G-protein activation dysregulated in disease, these findings warrant the exploration of therapeutic

LUAD cells drives TAMs migration and polarization, and blockade of A2aR may support a novel and potent therapeutic

We suggest that SST2 and SST3 should be further explored as potential biomarkers and therapeutic tools

heterogeneously in glioblastoma (GBM) and is involved in the mesenchymal transition, making it a promising therapeutic

To explore the therapeutic potential of GPR132 signaling, we screened and validated a natural product

of Canada (2014), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics

a causal link between microbial regulation of ISCs and colitis exacerbation and yielding a targeted therapeutic

interesting results pave the way to further investigations on both the mechanism involved and the possible therapeutic

Optimization of Candidate Molecules GPCRs have been and arguably still are the most prolific and fertile therapeutic