Fine-tuning GPCR signaling: conformational dynamics and intracellular responses GPCR signaling is a complex Following extracellular stimulus detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang, Y. et al. 2015, Chen, Q. et al. 2021), that allow interaction with trimeric the plasma membrane, certain receptors retain their active conformation during internalization and intracellular

membrane is a thin layer of lipids that surrounds the entire cell allowing the differentiation between the intracellular and extracellular environment.

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37

described by the two-step/two-site model - the first step characterized by the interaction between the extracellular CRS1); and the second step featured by the interaction between the N-terminus of the chemokine and the extracellular

In addition, our results suggest a previously unknown sodium-binding site located in the extracellular

contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular

Additionally, the dimeric state allows rotational movement of the receptor's extracellular domain (ECD

receptor F1 ( Adgrf1) GPCR Activation and Signaling Single-molecule analysis reveals that a glucagon-bound extracellular

GPCR contributor article Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted

role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway Unraveling the Interplay of Extracellular

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist

G-protein-coupled receptor rhodopsin activation GPCR Binders, Drugs, and more Chimeric antigens displaying GPR65 extracellular

structural, functional, and therapeutic perspective Structural basis for selectivity and antagonism in extracellular

Adhesion GPCRs Crystal Structure of the Extracellular Domains of GPR110.

Norcross 2008); and are also too small to be engaged by antibodies, which can only interact with the extracellular

) receptors and their ligand from the tick Ixodes scapularis Evidence that pyrophosphate acts as an extracellular

angiostatic activity GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular

of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular

(GPCRs) are a vast family of membrane-bound proteins crucial for transmitting external stimuli into intracellular via β2AR-Gs mediated activation, which subsequently transactivates purinergic receptors through Gq in intracellular Stallaert, W., et al., Purinergic Receptor Transactivation by the β(2)-Adrenergic Receptor Increases Intracellular

August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be Recording from specific neuronal populations, we can quantify intracellular signaling while simultaneously

However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location

mechanism involves internalization and recycling of the receptor with clearance of the ligand from the extracellular

Evidence demonstrated that the ligation of SDF-1 to CXCR4 initiates several intracellular signaling pathways

effectors, there is increasing appreciation for the elegance of the regulatory mechanisms that mediate intracellular

formation "The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular Moreover, we showed that FLNA regulates SST2 and SST5 intracellular trafficking induced by octreotide

October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular

GPCR-arrestin assemblies, associated with an original V2R/β-arrestin1 interface involving all receptor intracellular

Depending on which ligand activates a receptor, it can engage different intracellular transducers.