not only the way we understand how aGPCR works but might also provide a guide to how pharmacological approaches I said yes as soon as they approached me. New Insights Members Torsten Schöneberg and Ines Liebscher present an interactive browser-based application

cellular responses such as proliferation, differentiation, migration, survival, growth, growth arrest and apoptosis The gravity of this regulation becomes even more apparent when we consider the potential consequences that selectively modulate this specific pathway, improving efficacy and safety profiles in clinical applications ERK-dependent apoptosis as a potential therapeutic strategy for cancer. Cells, 10(10), 2509.

Unlike previous studies that provided only static snapshots, this approach captures the entire activation Beyond GPCRs, the methods and insights from this study can be applied to other fast, transient biological This approach is valuable for understanding the dynamics of other complex signaling pathways and molecular

Let’s dive into the Classified GPCR News from April 29th to May 12th, 2024 Adhesion GPCRs Essential Role

solutions have been the development of the BERKY and the ONE-GO biosensors, designed to facilitate their application

April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure In the United States, DNA Day was officially celebrated on April 25th, 2003. Eventually, April 25th was declared and recognized as International DNA Day1. Additionally, genomic approaches such as transcriptomics and proteomics have provided insights into the Furthermore, computational genomics approaches, such as structural bioinformatics analysis, have facilitated

to individual registrations This course will take a practical approach to Dr.  Terry Kenakin’s Applying Pharmacology to Drug Discovery course. Take advantage of the early bird registration until April 18th, 2024, to save 25%! event in Birmingham, UK, on April 22-23, 2024. 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

An alternative and promising approach is allosteric modulation.

If you have a few minutes to spare and have participated in our symposiums, we would appreciate it if GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. Events, Meetings, and Webinars March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

GPCR University Course, ‘Applying Pharmacology to Drug Discovery,’ led by Dr. GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. Discovery of potential TAAR1 agonist targeting neurological and psychiatric disorders: An in silico approach 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

evidence suggests that GPCRs also signal from intracellular membranes including endosomes, the Golgi apparatus In addition to endosomal signaling, GPCRs are also known to localize to the Golgi apparatus, where they pharmaceutical challenges associated with tagging GPCRs expressed in cellular compartments require innovative approaches

GPCR University Today marks the conclusion of the Dr.GPCR University course, ‘Applying Pharmacology to If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

GPCR University course, 'Applying Pharmacology to Drug Discovery,' led by Dr. If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

GPCR University Last week marked the beginning of our first Dr.GPCR University course, 'Applying Pharmacology If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join our Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

GPCR University This week marks the beginning of our first Dr.GPCR University course, 'Applying Pharmacology If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com. Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham , UK, on April 22-23, 2024. 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

Xavier Leroy on his appointment as CEO of GIO Therapeutics! We appreciate your enthusiasm and interest in advancing your knowledge with us. If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com. Dr. Xavier Leroy appointed as CEO of GIO Therapeutics GPCR Events, Meetings, and Webinars NOW! 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

GPCR University course, Applying Pharmacology to Drug Discovery, led by Dr. April 22 - 23, 2024 | Endocrine Metabolic GPCRs  Join Dr. GPCR at the Endocrine Metabolic GPCRs Summit on April 22-23, 2024, in Birmingham, UK. Dr. G protein Signaling 14 Ameliorates NAFLD through Activating cAMP-AMPK Signaling by Targeting Giα1/3 APOL1 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join us at the Endocrine Metabolic GPCRs event on April Unveils MolFlux: Empowering the ML Community in Molecular Predictive Modelling NanoImaging Services Appoints and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April

Congratulations to Domain Therapeutics for appointing Michael Gottlieb as Chairman and Dr. Potential Therapeutics for Psychiatric Disorders Structural and Molecular Insights into GPCR Function Apelin and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

chemosensory-related gene families in gastropods Unraveling the G protein-coupled receptor superfamily in aphids Morgan Healthcare Conference Andrew Hopkins appointed CBE by HM King Charles III Voyager Therapeutics and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

The therapeutic approaches mainly include small molecule inhibitors, as well as monoclonal antibodies The anti-CCR4 antibody mogamulizumab has also been approved in Japan and by the FDA for the treatment Therefore, an alternative approach is to make use of chemokine receptors redundancy and the fact that of administration are particularly rigorous for this class, as the majority of potential therapeutic applications

We appreciate your continued support and readership. with focus on the receptor-binding domain of SARS-CoV-2 Microscopy and spectroscopy approaches to study and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

Clinical Studies AbbVie to acquire neuroscience drugmaker Cerevel Therapeutics for $8.7 billion FDA approves and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach GPCR Research Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

AlphaFold2-multimer models and interface interactions Experimental modulation of physiological force application and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024

in E. coli-based cell-free and whole cell expression systems A high-throughput structural dynamics approach Meiling Lim TRUQAP™ (capivasertib) plus fulvestrant approved in the US for patients with advanced HR-positive and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry NEW April 4 - 7, 2024 | American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17