One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells, such as GPCR-family kinin receptors, and proteases that control tumor progression, such Considering the multiple functions of kinin receptors and KLKs, this review highlights their roles, even considering the SARS-CoV-2 effects. , Kinins , Lung cancer , SARS-CoV-2 Source Contribute to the GPCR News Coming soon Become a Contributor

hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase Published date November 13 , 2024 Abstract "G protein-coupled receptor (GPCR) signaling regulates a wide range of pathophysiological TGF-α-stimulated phosphorylation of JNK without affecting the phosphorylation of epidermal growth factor receptor

in Oncology and Immunology The landscape of cancer-rewired GPCR signaling axes Published date May 8, 2024 Abstract "We explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems in cancer We derived an interaction network of receptors with ligands and their biosynthetic enzymes. The expression of both receptor-ligand (or enzymes) partners improved patient stratification, suggesting from these actionable axes, including, e.g., muscarinic, adenosine, 5-hydroxytryptamine, and chemokine receptors

graduate school at the University of California at Irvine, studying the regulation of ionotropic glutamate receptors , Oregon, to do a post-doctoral fellowship in the laboratory of Thomas Soderling studying glutamate receptor continued his post-doctoral training at Duke University, where he studied the regulation of adrenergic receptors contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors In 2014, he was named a Fellow of the AAAS.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr.

associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma Published date September 27 , 2023 Abstract "Aims: Epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling (2003-2016). His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

decreases trabecular bone but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions cell lineages using an engineered receptor strategy, developed a fibrotic bone phenotype with trabecularization controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid receptors There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until 2018 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and I investigated the effect of lung cancer-related mutations in the GAIN domain of the Latrophilin 3 receptor

a premier scientific meeting bringing together leaders and innovators in G Protein-Coupled Receptor discussions, workshops, and networking sessions covering the latest advancements and challenges in Membrane Receptor Opportunity to be designated in print on the 1 st ever “aGPCR Excellence and Mentoring Award” Customized Complimentary registration for 2 representatives. Complimentary registration for 1 representative.

Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer Hamm 2 1 Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center , Nashville, TN 37232, USA 2 Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, Current areas of interest include Protease Activated Receptor signaling in the cardiovascular system and regulation of vesicular exocytosis mediated by Gi/o-coupled receptors by G subunit binding to SNAREs

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the molecular and cellular levels over the last 20 years, particularly involving GPCRs. globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers.

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled receptor (GPCR) responses, a class of receptors involved in many, if not all, physiological responses, with the He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and They also discussed their own research on chemokine receptors and the importance of understanding the and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors They also delved into the different signaling of Class B receptors and the potential for modulation at

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to : RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular She currently serves as Associate Editor of Physiological Reviews; the #1 ranked journal in Physiology

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels GPCRs in regulating renal and cardiovascular function, and identifying renal/cardiovascular olfactory receptor

Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

Lefkowitz (Nobel Laureate, 2012) at Duke University. Dr. Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor