Search Results
81 items found for "Ji'ou Gu"
- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34 "Functional advances have guided
- Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
LINKED ARTICLES: This article is part of a themed issue on Structure Guided Pharmacology of Membrane
- Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
Our findings fill a gap in the understanding of CB1 allosteric regulation and could guide the rational
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
orientational selection supporting complex formation of a GPCR and a middle sized flexible molecule "A GA-guided
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
identifies small changes to the ligands that invert their pharmacological activity and thus helps to guide
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
The TM domain acts as a functional component of Cya, guiding the assembly of the catalytic domain and
- Dr. Rosie Dawaliby Podcast!
Our guest is the wonderful Dr. Rosie Dawaliby! Watch the full video with a Dr.
- Carola Weiss joins InterAx Biotech AG as VP Business Development
Her expertise guided numerous global negotiations, conclusions of partnership agreements, and fostered
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
of GPR84 may potentially prove effective also in diseases associated with inflammation of the lower gut
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
Experimental approach: We used a bio-guided screening assay to identify novel MQs and placed them phylogenetically
- Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold guided
- Exscientia is 10 years old this July!
candidates to enter clinical trials, the first AI-driven precision medicine platform clinically validated to guide
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
drug discovery programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain biopharmaceutical company, and New York City-based Kallyope , pioneers in drug discovery involving the gut-brain
- Dr. Juan José Fung - Dr. GPCR Podcast
Our guest is none other than Dr. Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.
- Unconventional GPCR-PKA Communication in the Hedgehog Pathway
Our first guest speaker is none other than Dr. Ben Myers!
- Mark Schmeizl - Dr. GPCR Podcast
Our guest is Mark Schmeizl!
- Melatonin MT 2 receptor is expressed and potentiates contraction in human airway smooth muscle
detected the mRNA and protein expression of the melatonin MT2 but not the MT1 receptor in native human and guinea formation through the MT2 receptor in HASM cells, and attenuated the relaxant effect of isoproterenol in guinea
- SLAS2022 International Conference and Exhibition
Please refer to our Safe Meeting guidelines for information about how you can participate in the event
- Dr. Peter Robert Banks - Dr. GPCR Podcast
Our guest is Dr. Peter Banks, Scientific Director at BioTek Instruments!
- Dr. Adriano Marchese - Dr. GPCR Podcast
Our guest is Dr. Adriano Marchese!
- Dr. JoAnn Trejo - Dr. GPCR Podcast
Our guest is Dr. JoAnn Trejo!
- Dr. Tim De Groof - Dr. GPCR Podcast
Our guest is Dr. Tim De Groof!
- Dr. Ben Myers - Dr. GPCR Podcast
Our guest is Dr. Ben Myers!
- Dr. Mark Connor - Dr. GPCR Podcast
Our guest is Dr. Mark Connor!
- All About Addgene: More Open and Reproducible Science with Materials Sharing
Joanne Kamens is our guest.