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81 items found for "Jingbai Zhang"
- Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Here, we investigate the conformational changes induced by the binding of a nanobody (Nb80) on the active-like
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and These interactions induce local conformational changes which are amplified and transmitted to the intracellular the fully integrated PROcisionXᵀᴹ discovery platform Structure-based validation of Orion’s approach Zheng
- 📰 GPCR Weekly News, April 1 to 7, 2024
Farma Reports Its 2023 Annual Financial Resultsand Confirms Its 2024 Outlook Sosei Heptares officially changed
- 📰 GPCR Weekly News, March 4 to 10, 2024
from March 4th to 10th, 2024 GPCR Activation and Signaling Glu1022.53-Mediated Early Conformational Changes
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling
- 📰 GPCR Weekly News, March 6 to 12, 2023
de l'Innovation Technologique (Technological Innovation Award) Sosei Heptares Receives Approval for Change
- 📰 GPCR Weekly News, September 25 to October 1, 2023
Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- 📰 GPCR Weekly News, September 18 to 24, 2023
Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- 📰 GPCR Weekly News, September 11 to 17, 2023
Lefkowitz's Career at Duke October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Drug Targets: Allosteric Function and Biased Signaling" at the DOT NEW October 3, 2023 | FREE Seminar: Changing
- 📰 GPCR Weekly News, February 5 to 11, 2024
cAMP signaling in the Hedgehog pathway Unraveling the Interplay of Extracellular Domain Conformational Changes
- 📰 GPCR Weekly News, April 24 to 30, 2023
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.
- 📰 Breaking Down the Latest GPCR Discoveries: a Weekly Update (Nov 27-Dec 3, 2023)
Allostery of G-Protein-Coupled Receptors Industry News Sosei Heptares to take back GPCR agonist after GSK changes
- 📰 GPCR Weekly News, November 13 to 19, 2023
cannabidiol, on the cannabinoid CB2 receptor GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic changes
- 📰 GPCR Weekly News, March 13 to 19, 2023
GPCRs in Neuroscience Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain
- 📰 GPCR Weekly News, February 12 to 18, 2024
multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology Common changes
- 📰 GPCR Weekly News
Quantification of changes in human islet G protein-coupled receptor mRNA expression in obesity.
- 📰 GPCR Weekly News, June 17 to 23, 2024
mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific behavioral and transcriptomic changes
- Nanobodies: New Dimensions in GPCR Signaling Research
They have also been used as biosensors to monitor conformational changes of GPCRs in living cells.
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
announced the winners of its Transforming Cancer Therapeutics grant, which focuses on developing life-changing
- Targeting Intracellular Allosteric Sites in GPCRs
or more of the following pharmacological characteristics: 1) affinity modulation where the resulting change
- 📰 GPCR Weekly News, March 25 to March 31, 2024
Sosei Heptares Confirms Re-election of its Board and Executive Management Team and the Approval of Change
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
2000), becoming incapable of promoting cell migration, a phenomenon which is likely to be mediated by changes
- Glyco-sulfo hotspots in the chemokine receptor system
extracellular loops and transmembrane domains of the receptor (CRS2), which will trigger conformational changes
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
, such as ligand binding sites (orthosteric, allosteric), activation mechanisms, and conformational changes