Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these UCA1 , lncRNA Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Furthermore, expression of GPR30 in MCF7 cells constitutively and PDZ-dependently inhibits β1AR-mediated These results argue that GPR30 and β1AR form a PDZ-independent complex in MCF7 cells through which GPR30 adrenergic receptor Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Beatriz Blanco Redondo The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Collectively these proteins form a cell surface complex that acts as a recognition platform for Wnt ligands Scholar X (Twitter) The Adhesion GPCR Latrophilin Interacts With The Notch Pathway To Control Germ Cell Anette 4, Ließmann Fabian 5, Meiler Jens 5, Schöneberg Torsten 2,6, Prömel Simone 1 1 Institute of Cell Willem Berend Post on the web Cell Biology LinkedIn < Previous Session Next Session >

Felix B. Engel. G-protein-coupled receptors, which exhibit large multi-domain extracellular N-termini that mediate cell-cell and cell-matrix interactions. Renal Adgrf5 is restricted to two distinct populations of cells: AICs and endothelial cells (ECs). These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney.

receptor-ligand interactions are highly relevant for its different physiological effects, e. g. the migration of immune cells towards sites of inflammation. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Immunology Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell However, the role of β2-AR in oral cancer is not well identified. significance in relation with the clinicopathological features and overall survival of oral squamous cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to RNA-seq analysis, 3D growth, in situ- and immunofluorescence analyses, and cell viability- and motility Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells Single cell in situ analysis of MCF-7 cells revealed that several GPR81-regulated genes were upregulated in the same cell clusters.

Low extracellular pH confers radioresistant tumors to glial cells. inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway: ferroptosis Next, A GPI-anchored pH reporter, pHluorin2, was stably expressed in U87 glioblastoma cells to probe Cell survival assays, via nuclei counting and cell titer glo, were used to demonstrate sensitivity to To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq.

for a randomised controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell post-COVID syndrome Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss, The concurrent loss of ITGAE, CXCL16, and CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity against viral diseases and vaccines inducing CD8 TRM cells."

2024 Abstract "Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells as induce T helper 17 (Th17) cell differentiation leading to elevated production of interleukin 17 ( In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected abnormal proliferation as well as Th17 cells differentiation. Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function

GPR37 gene expression and the clinicopathological factors, patient prognosis, tumor-infiltrating immune cell Besides, the "ssGSEA" algorithm was conducted to estimate immune cells infiltration abundance, with ' differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand receptor , CD8 T cell, eosinophils, macrophages, neutrophils, NK CD56dim cells, NK cells, plasmacytoid DCs (pDCs ), T helper cells and T effector memory (Tem) cells.

a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within cells Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews, Amanda B Gary C Chan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

to reveal the spatial and temporal requirements for GPCR activation of signaling pathways related to cell survival, proliferation, and migration.

Here we reported the first comprehensive proteogenomic characterization of natural killer/T-cell lymphoma Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma cell killing in NKTCL organoid.

previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts and which cells Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. ligands were up- or downregulated in different cellular populations, including in non-osteoblastic cells

Experimental design: We performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML. understand the co-occurring mutation patterns and further investigated the mutation profiles in the single cells The application of single-cell genomic sequencing unveiled the co-occurrence of variants at the individual cell level, highlighting the presence of distinct subclones within patients with AML.

Planar cell polarity (PCP) proteins contribute to tumour growth and invasion. protein isoforms differentially regulate tissue adhesiveness by influencing the stability/plasticity of cell-cell and cell-matrix contacts. assays in vitro and in vivo, whether CELSR1 protein isoforms differentially influence the stability of cell-cell and/or cell-matrix adhesions to dictate breast tumour invasive mechanism (b) quantify CELSR1 isoform

Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently fatty acids Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

also associated with a significant disruption in their cellular metabolism and a decreased ability to migrate Authors Magdalena B Flak , Duco S Koenis , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Adhesion GPCRs September 25, 2024 The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration Read More September 12, 2024 Loss of cardiomyocyte-specific Adhesion G Protein Coupled Receptor BRET-Based Sensors Shed Light on Cellular Signaling Read More Read more articles from our Contributors Call

receptors, are the targets of multiple drugs displaying anti-growth effects in large-scale, cancer cell , Guanming Wu, Gioacchino Natoli, J Silvio Gutkind , Francesco Raimondi Tags GPCR , cancer , cancer cell lines , cell-cell communication , drug repurposing , personalized medicine , signaling network , survival Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and cells Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors , Therapeutic targeting , Tumor cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

transmitting signals inside the body, which is necessary for controlling the life activities of all cells , including tumor cells [1]. ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune cell microenvironment (TME) Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Mesenchymal cells play key roles in numerous developmental processes. subunits Gαq and Gα11 (Gαq/11) transmit mechanical and chemical signals to activate TGFβ in epithelial cells exhibited abnormal alveolar development, with suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 deposition, as well as kidney abnormalities. undescribed mechanism of cyclical stretch-induced Gαq/11-dependent TGFβ2 signalling in mesenchymal cells

Depletion of GPR37 significantly reduced CRC tumor cell growth both in vitro and in vivo. Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 SCD1 , p38 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration morpholino-mediated knockdown of blt2a or chemical inhibition of BLT2 signaling impairs macrophage migration applicability of our zebrafish findings to mammals by showing that macrophages of Ltb4r2-/- mice have defective migration Collectively, our results demonstrate that BLT2 mediates macrophage migration during inflammation, which