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118 items found for "Keywords: Systems Pharmacodynamic"
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
linking them to pseudo-allergic drug reactions and suggesting a pivotal role in the cardiovascular system Overall, the observation that MRGPRD mediates the release of IL-6 in an in vitro system, hints at a role
- Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
the G-protein interface "Galanin is a neuropeptide expressed in the central and peripheral nervous systems
- G protein coupling and activation of the metabotropic GABAB heterodimer
class C G protein-coupled receptor (GPCR) heterodimer, plays a crucial role in the central nervous system
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
antibody fragments from camelids, have become indispensable tools for interrogating GPCRs both in purified systems
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune system
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
considered promising agents to treat Parkinson's disease, inflammation, cancer, and central nervous system
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
conditions such as Alzheimer's disease and multiple sclerosis, in the recovery from central nervous system
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer
- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
triagonists are included which have demonstrated their safety, efficacy, and beneficial effects on the CV system
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
a G protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune system
- 📰 GPCR Weekly News, September 4 to 10, 2023
symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system Methods & Updates in GPCR Research Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts GPCRs in Neuroscience System-wide Physiology, and Pharmacological Perspectives COVID-19, G protein-coupled receptor, and renin-angiotensin system
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
of the secretin/adhesion (Class B) G protein-coupled receptors in the regulation of cardiovascular system
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
using live-imaging modalities, and displayed high efficiency when used to label complex 3D cellular systems
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the PK2/PKR2 system
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system
- Trevena Announce Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu ...
focused on the development and commercialization of novel medicines for patients with central nervous system
- 📰 GPCR Weekly News, November 13 to 19, 2023
transition of glioblastoma Methods & Updates in GPCR Research Optogenetic Microwell Array Screening System small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
The mGlu5 receptor is activated by the main excitatory neurotransmitter of the nervous central system
- Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
studies provided evidence for the existence of a functional gonadotropin-inhibitory hormone (GnIH) system
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
have entered phase Ⅱ clinical trials for idiopathic pulmonary fibrosis (BMS-986020 and BMS-986278) and systemic
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
complex formation of a GPCR and a middle sized flexible molecule "A GA-guided multidimensional virtual-system
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
therapies against, for example, inflammatory bowel disease or bacterial infections of the gastrointestinal system
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled (GPCR) signaling systems
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
proteins, and the disruption of natural spatial and temporal signaling patterns regulated by physiological systems processes like neurotransmission and chemokine signaling, extending to numerous other GPCR-regulated systems
- 📰 GPCR Weekly News
A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson's Oligomerization of the heteromeric γ-aminobutyric acid receptor GABAB in a eukaryotic cell-free system