However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models

The completion of the Human Genome Project revealed that GPCR genes in the human genome range from approximately

“ A substitution of one amino acid by another in a protein can have effects ranging from negligible to