Search Results
83 items found for "Mary-Elizabeth M Percival"
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
GPCR) superfamily, and its ligand fractalkine constitute an important biochemical axis that influence many
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
Therefore, mGluR2 and mGluR3 have been considered as potential drug targets for the treatment of many
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play a key role in many
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
cancer cell cycle and metastasis "β-Arrestins are ubiquitously expressed intracellular proteins with many
- Comparative study of neuropeptide signaling systems in Hemiptera
Neuropeptides and their receptors have been documented in many hemipteran insects, but the differences
- Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
At the same time, H2R as a GPCR imparts many unresolved questions, such as the functional relevance of
- Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
S1R has been implicated in many neurological disorders such as anxiety, schizophrenia, and depression
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the targets for many
- Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
these variants exhibit a loss of function, the molecular defects caused by these underlying mutations vary However, the magnitude of the response to this molecule varies considerably across this spectrum of mutations Nevertheless, estimates from computational modeling suggest that many of the least sensitive variants
- Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
However, our predictions were many folds shorter than those determined experimentally.
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
October 2022 "Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases
- GPCR voltage dependence controls neuronal plasticity and behavior
Thus, this study suggests that GPCR voltage dependency plays a role in many diverse neuronal functions
- Phospholipid Scrambling by G Protein-Coupled Receptors
Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for many Expected final online publication date for the Annual Review of Biophysics , Volume 51 is May 2022.
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
is better than AlphaFold's 5.53 Å and RoseTTAFold's 6.28 Å, probably since Modeller already included many
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
cavities at the receptor-lipid interface represent an uncharacteristic binding location that raises many
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
to respond to a highly diverse range of chemical stimuli, they represent the therapeutic targets for many
- Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
Not Correlate with Kisspeptin Signalling and Migration "Kisspeptin is an anti-metastatic mediator in many is related to the observed differences in β-arrestin complements warrants further investigation and may
- Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic ...
Like many other organs, various GPCRs play a role in regulating liver function. the role of GPCRs in hepatic stellate cells (HSCs), the primary cells that regulate liver fibrosis, may
- Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors
Many cause receptor misfolding and failure to reach the cell surface.
- G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
receptors (MCR3), as well as the MCR3 accessory protein, MRAP2, providing possible mechanisms for its many
- A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent ...
Finally, we report that JQ1 treatment downregulated expression of many GPCRs and also impaired ERK1/2
- 📰 GPCR Weekly News, October 23 to 29, 2023
Find speaker details on the Live Talks page and mark your calendar HERE. extracellular calcium pathways Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024 | AACR Annual Meeting May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, March 20 to 26, 2023
The delisting dilemma: Why do so many biotechs face being kicked off the Nasdaq?. (May 22 - 26, 2023) 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023) 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).
- 📰 GPCR Weekly News, November 13 to 19, 2023
agonists of FFAR4 for type 2 diabetes mellitus therapy Industry News OMass Therapeutics Welcomes Melissa Faris Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic GPCRs May 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- 📰 GPCR Weekly News, May 29 to June 4, 2023
Below is your Classified GPCR News at a glance for May 29th to June 4th, 2023. Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes.
- Glyco-sulfo hotspots in the chemokine receptor system
GalNAc-Ts, GalNAc-T1 was shown to be the most likely candidate for directly glycosylating CCR5 although T11 may are important PTMs in chemokine receptor biology and pharmacology however the reported effects can vary although direct effects of O-glycosylation removal are ruled out it is possible that indirect effects may also contribute to the observed phenotype since many glycosyltransferases and the two TPSTs also carry understanding on the dynamics and biological relevance of these PTMs in the chemokine receptor system which may