emerging interest in defining if agonists of GPR84 might find utility in conditions in which regulation of metabolism

The CCL2/CCR2 pathway plays an important role in oncology, inflammatory, metabolic, and neurological

compound with high biological potency in inhibiting cell migration together with improvements of the metabolic

roles for C3aR in regulating innate immune cell inflammatory state, antimicrobial killing capacity, and metabolism

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with a focus on small molecules and monoclonal antibodies for the treatment of cancer, infections, metabolic

target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism

hormone 1 receptor (PTH1R), a class B GPCR and an important modulator of mineral ion homeostasis and bone metabolism

The GLP-1R, a class B1 GPCR, is integral to metabolic regulation, particularly in glucose homeostasis biased agonism at the GLP-1R represents a promising strategy for optimizing therapeutic outcomes in metabolic

mutations in the ADGLR3 gene disrupt the standard and wild ADGRL3 structure, most likely affecting its metabolic

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of CXCR4 attenuates CXCL12-induced signaling and cell migration Respiratory infections predominate after by spinal cord injury-induced immunodeficiency G protein-coupled receptors: A target for microbial metabolites

Obesity, immunological diseases and endocrine metabolic diseases are high-risk factors for the development

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pharmacologic activities and potential therapeutic utility toward diseases of bone and mineral ion metabolism

in treating depression was involved in the biological process of GPCR signal transduction, hormone metabolism

critical myocardial signal transducers which regulate cardiac contractility, growth, adaptation and metabolism

eukaryotes is the phosphoinositide 3-kinase (PI3K) pathway, which plays fundamental roles in growth, metabolism

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September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an

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Alterations in gene expression appear in pathways related to primary cilia (PC). Inhibition of this pathway rescues the alterations in PC morphology and mitochondrial dysfunction.

extend to regulation of neurogenesis, learning and memory, gastrointestinal motility, glucose/lipid metabolism

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We demonstrate in male and female rats that GABAB receptors receptors alter Pr, whereas 5-HT1B receptors sophisticated hippocampal output filter that itself is modulated by colocalized GABAB receptors which alter GABAB receptors alter Pr leaving synaptic properties unchanged, while 5-HT1B receptors fundamentally Co-activation of these receptors allows synaptic integration because of convergence of GABAB receptor alteration on Ca2+ and the effect of this altered Ca2+ signal on 5-HT1B receptor signaling.

biarylamine acting as agonist at human β3 adrenoceptors and exerting BRL37344-like effects on mouse metabolism

Intellectual Property Portfolio with Granted Patent in Japan Proteros Biostructures GmbH Revolutionizes Metabolic

Scientist/Senior Staff Scientist, Disease Biology and Translational Sciences Senior Scientist, Drug Metabolism