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131 items found for "Metabolomic alterations"
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- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
gene deletion exhibited abnormal alveolar development, with suppressed myofibroblast differentiation, altered
- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
The concurrent loss of ITGAE, CXCL16, and CXCR6 in chickens may have altered CD8 TRM cell abundance,
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
asbestos cancer risk implied by new inflammation-mutation model Published date August 1, 2023 Abstract "Alterations
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
indispensable and this adhesion receptor may affect immune cell enrichment and function in skin and alter
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- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
Alterations in GPCR gene expression and dysregulation of signal transduction have been recognized as
- GPCR Retreat 2023 - Part II
at the University of Calgary in 2010 for his Ph.D. where he studied the molecular basis underlying altered
- Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions
These GPCR-type and cell-type specific effects reflect in altered lymphocyte chemotaxis in vitro and
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
diseases and the importance of the development of antibodies against CCR6 that could be a promising alternative
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
In this ECR-mediated mechanism of activation, the ECR-7TM communication is altered by transient interactions After finishing her graduate training, she joined Dr.
- Ep 41 with Dr. Terry Kenakin
Terry Kenakin After obtaining a BSc in chemistry at the University of Alberta Edmonton Canada, Terry After 7 years at BW, Dr.
- Ep 14 with Dr. Bryan Roth
After receiving his MD and Ph.D. in Biochemistry from St. Bryan got fascinated with receptors after attending the lecture of a visiting professor on neurotransmission
- Ep 141 with Dr Tobi Langenhan
After returning to Germany I set up my own lab at the Institute of Physiology at Würzburg, where I later Shortly after was recruited to the Medical Faculty of Leipzig University, where I now head the Department
- Session VI | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal and metabolism
- Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
After 2-24 h, brains were collected for the analysis of gene expression by RT-PCR or protein expression The LPS-induced Iba-1 expression in the brain was significantly higher after ethanol pretreatment in PDE4B expression at both mRNA and protein level in the brain increased after ethanol and LPS treatment
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
enriched in the GO term immunoregulation, indicating that splenic immune function was markedly impaired after study assessed the differential regulation of the gene network associated with neuroendocrine immunity after Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled
- Ep 26 with Dr. Debbie Hay
is presently a professor at the Department of Pharmacology and Toxicology at the University of Otago after
- Ep 76 with Steve McCloskey
After graduating from UCSD he founded Nanome Inc to build Virtual Reality solutions for Scientists and
- Ep 21 with Dr. Maria Waldhoer
After working in the US and at the University in Graz in Austria, Maria worked several years at Novo
- Ep 81 with Dr. Christel Menet
After 2 years, I joined Galapagos where I spent almost 11 years and became head of medicinal chemistry
- Ep 30 with Dr. Elva Zhao
After her Ph.D., she moved to Australia and continues working on GPCRs.
- Ep 124 with Gáspár Pándy-Szekeres
GPCR Podcast << Back to podcast list Gáspár Pándy-Szekeres About Gáspár Pándy-Szekeres " After a BSc
- Ep 138 with Dr. Daniel Isom
After spending two years at the Cleveland Institute of Art, he earned degrees in Biochemistry and Chemistry
- Ep 123 with Dr. Lukas Grätz
Lukas Grätz "After a BSc in biology and a MSc in bioinformatics, I have been working in David Gloriam's
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
RGS6 was expressed in the cytoplasm and accumulated in the nucleus after LPS stimulation. slower alveolar organoid formation, fewer alveolar organoids, and impaired development of new structures after
- Ep 50 with Dr. Thomas P. Sakmar
After medical school and clinical training at Massachusetts General Hospital, Tom joined the laboratory After moving to Rockefeller University with a Howard Hughes Medical Institute appointment, Tom advanced of “functional micro-domains” and the “helix movement model of receptor activation” were confirmed later