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Tilley, D. G. D. Regulation of nuclear factor κB activation by G-protein-coupled receptors. Plouffe, B., Thomsen, A. R. B. & Irannejad, R.

However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior In contrast to Gpr3-deficient mice, G protein-biased GPR3 mice do not display elevated anxiety levels suggest a protective glial response that may limit amyloid plaque development in G protein-biased GPR3 AD mice

of C265 augments β2AR protein kinase A signaling, enables β2AR nitric oxide (NO) signaling, renders mice resistant to bronchoconstriction, and protects mice from allergen-induced asthma."

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in we demonstrate that intra-PVT injections of NPS can rescue the phenotype in NPS precursor knockout mice salience of otherwise low-intensity stimuli, while intra-PVT injections of NPSR1 antagonist in wild type mice

tissues of active ulcerative colitis (UC) patients and dextran sulfate sodium (DSS)-induced colitis mice GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients and the mice Consistently, GPR84-/- mice are resistant to the development of colitis induced by DSS.

Araç, D., et al., A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

uniquely rod phototransduction, we generated transgenic rods expressing Gγ1, Gγc, or Gγ11 in Gγ1-deficient mice However, Gαt1 translocation in Gγ11 transgenic mice occurred at significantly dimmer background light recordings revealed gradual response recovery in moderate background illumination in Gγ11 transgenic mice

Recent studies revealed butyrate and secondary bile acids, produced by the intestinal microbiome, potentiate RNA sequencing of intestinal epithelial cells responding to butyrate and secondary bile acids in combination

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice.

Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration

Azodopa increases the overall neural activity in the cortex of anesthetized mice and displays illumination-dependent

Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice. Dr. receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice

mouse expressing a non-cleavable GPR116 mutant phenocopies the pulmonary phenotype of GPR116 knock-out mice

GPCR Activation and Signaling Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

Finally, inhibition of Gq-GPCR coupling in mice enhanced the antinociceptive effects of morphine.

TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice.

effect of CCL25 on the development of SACC in vivo was examined by a xenograft tumor model in nude mice

In adult mice, intraperitoneal ketanserin injection increased basal TrkB phosphorylation in the frontal

He has led teams that have filed more than 10 Investigational New Drug Applications (IND), as well as

to E2837.39 by A4 of CCL3; c) Route 3 - characterized by steric effects between TM2 and Y3 of CCL5; d)

protein (YAP) signaling in endothelial cells, which was evidenced by the attenuation of organ fibrosis in mice

inhibition of cell proliferation, colony formation, migration, invasion and xenograft tumor growth in nude mice

formation by PDAC cells and suppessed the growth of MiaPaCa-2 cells xenografted into the flank of nude mice

ARRB1 alleviates tauopathy and rescues impaired synaptic plasticity and cognitive impairments in PS19 mice

characterized by decreased levels of proinflammatory cytokines, glial activation, and cognitive impairment in mice

MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like