Search Results
76 items found for "Miles D Thompson"
- Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
In in vivo set-up, weekly intraperitoneal administration of Peptidase M84 in syngeneic mice significantly
- CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes
Antigen exposure in mixed-chimeric Ccl5-, Ccr2-, Ccr5-, Ccr7-, and Batf3-deficient mice demonstrated
- Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific Adra2a knockout mice
- Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation
established the applicability of our zebrafish findings to mammals by showing that macrophages of Ltb4r2-/- mice
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
Through gain- and loss-of-function studies in mice, we show that GPR143 promotes metastasis by secreting
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8
- The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils
Here, we identify C5aR1 and CXCR4 as direct Norbin interactors and used mice with myeloid-Norbin deficiency
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
lanthionine-constrained agonist of angiotensin II type 2 (AT2) receptor inhibited PDX of colorectal cancer in mice
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Metabolism 2023), recognition of amine containing hormones by GPCRs (Cell 2021, 2023, Nature 2023b), bile
- Advanced data analysis for GPCR pharmacology | Dr. GPCR Ecosystem
Attendees will be provided with Prism files, Excel templates and simulators, and the PowerPoints of the
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Methods: RGS5 knockout (Rgs5-KO) mice and RGS5 overexpression or knockdown in VSMCs in vivo by adeno-associated
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
formation by PDAC cells and suppressed the growth of Mia PaCa-2 cells xenografted into the flank of nude mice
- Session VI | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor growth and prolongation of survival of host mice.
- Ep 82 with Dr. Lauren M. Slosky
the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
inhibitory function of Pc(4-4) is demonstrated via inhibition of ovarian cancer peritoneal spread in mice
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
prostatic hyperplasia (BPH) are inflammations of the prostate gland, which surrounds the urethra in males Database-driven data mining and networking were utilized to establish a general correlation between Jinqiancao
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
less primary human T lymphocyte chemotaxis in vitro and peritoneal ingress of CXCR3+ T lymphocytes in mice
- GPCR Retreat 2023 - Part I
the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
Administration , VIP , Vasoactive intestinal peptide , Voltage-gated sodium channel , gamma chain , mAb , mIgE
- Classified News | Dr. GPCR Ecosystem
delivery of liposome encapsulated flavonoids ameliorates l-DOPA induced dyskinesia in hemiparkinsonian mice