Search Results
118 items found for "Nicolas Jaime Roth"
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
Microiontophoretically applied H1152, a ROCK inhibitor, and siRNA-induced ROCK2 knockdown both depressed Finally, two neurotransmitters, TRH, and 5-HT, which are both known to increase MN IME by TASK1 inhibition
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
Both CGRP populations and their amygdala projections are required for multi-sensory threat perception
- Orion Shares New Data on its Latest Best-in-Class Drug Candidate
Protein-Coupled Receptors (GPCRs), today announced that it will be presenting important new data at both
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
importance of functional selectivity/biased signaling has led to the discovery of biased compounds as both
- Immunomodulatory Role of Neuropeptides in the Cornea
The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
, in the case of promiscuous receptors they found that these receptors shared conserved residues of both G protein families, suggesting that receptors that activate both Gs and Gi/o do so by combining the
- Decoding β-Arrestins: from Structure to function
However, both methods struggle with flexible or dynamic regions. However, the evolutionary conservation of both isoforms from fish to mammals indicates their non-redundant Additionally, not all receptors recruit both isoforms equally and arrestins can undergo different conformational played a pivotal role in identifying essential effector proteins that modulate GPCR functions across both
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion
- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
Recently, X-ray structures of both AngII receptors (AT1 and AT2 receptors) bound to peptide and non-peptide
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
In contrast to A2AAR agonists, which simultaneously interact with both Ser2777.42 and His2787.43, 2 only
- Functional modulation of PTH1R activation and signaling by RAMP2
Additionally, RAMP2 increases both PTH- and PTHrP-triggered β-arrestin2 recruitment to PTH1R.
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
use of various drugs including orthosteric and allosteric ligands acting on either mGluR2, mGluR3 or both
- Professor Charlotte Deane Joins Exscientia as Chief Scientist of Biologics AI
She will maintain both of these roles, in addition to her role at Exscientia .
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
In this review, we discuss both the ‘friend’ and ‘foe’ features of TGR5 by summarizing its tumor-suppressing
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
a NanoBRET-based conformational histamine H3 receptor (H3R) biosensor that allowed the detection of both
- Discovery of 3(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligand
We have explored hydrophobic groups of different sizes on both sides of the five-membered ring scaffold
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
September 2022 "The diamondback moth (Plutella xylostella) is one of the most destructive lepidopteran
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
Although the high-resolution crystal structures of the DOR with both agonist and antagonist have recently
- TeachOpenCADD - A teaching platform for computer-aided drug design
Since we cover both the theoretical as well as practical aspect of these topics, the platform addresses
- Profiling Immune Cell and Platelet Transcriptomes
This analysis utilized a semi-quantitative multiplex PCR method, which allowed for the detection of both
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Recruitment of both β-arrestin1 and β-arrestin2 was significantly diminished iin Gαi KO and Gα_all KO Moreover, HEK293 cells with CRISPR KO of both β-arrestin1 and β-arrestin2 only led to a small but measurable
- Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
In the experiment, similar sets of residues were found to be in significant contact with both ligands
- Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
This is also where Gq/Gs bind the receptor through both hydrophobic and polar interaction, while Gi/G12
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
domain 1 (FnIII.1) suggest the cysteine-rich (CR) and the FnIII.1 domains could assist the WAP domain both
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
discussed that one should consider when attempting to compare functional outcomes from different studies, both