Search Results
88 items found for "Nicolas Jaime Roth"
- Ep 154 with Dr Badr Sokrat
They both discussed the intense competition in their home province, Quebec, and its impact on students Additionally, they both agreed on the importance of mentorship in building confidence, with Yamina sharing They both agreed on the value of these strategies. She aims for Dr. GPCR to serve as a global hub for the GPCR community.
- Ep 69 with Dr. Stephen Ferguson
He has also received both Junior (2001) and Senior (2005) investigator awards from the Pharmacological
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system, is expressed on both
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
blotting analysis showed that siGPRC5A (0.27±0.03, 0.71±0.00) suppressed the expressions of GPRC5A at both The siGPRC5A+LPS group (0.39±0.03, 1.06±0.16) also inhibited the increase of GPRC5A at both gene and
- CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes
Using two tracking methods, we observed that both CD88hiCD26lomonocytes and CD88-CD26hi cDCs captured
- Ep 87 with Dr. Bianca Plouffe
Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind
- The landscape of cancer-rewired GPCR signaling axes
The expression of both receptor-ligand (or enzymes) partners improved patient stratification, suggesting
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both Authors Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov
- Ep 43 with Dr. Stuart Maudsley
scientific journey with the award of the highly-valued Odysseus Program Type I Program Grant to work as both
- Ep 72 with Dr. Stuart Maudsley
scientific journey with the award of the highly-valued Odysseus Program Type I Program Grant to work as both
- Ep 78 with Dr. Stuart Maudsley
scientific journey with the award of the highly-valued Odysseus Program Type I Program Grant to work as both
- Ep 151 with Dr GPCR Board
Maria Waldhoer "I am a pharmacologist with a ~30 years background in academia and industry, working both After a well needed break from the grind, I am now a scientific/business consultant for clients both
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
In this study, we aimed to investigate the effects of cancer patient-derived 5-HT2C receptor mutations found that the affinity of the endogenous agonist serotonin (5-HT) and inverse agonist mesulergine were both
- Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes
Published date June 20, 2024 Abstract "The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through
- SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
and predicts poor prognosis in nasopharyngeal carcinoma Published date September 27, 2023 Abstract "Aims This study aimed to investigate whether SSTR2 is associated with EGFR and clinicopathological features of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis in both
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
are thought to involve modes of action driven by mutations, cytotoxicity-associated inflammation, or both
- Esophageal and gastric cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004 to 2018
Despite favorable trends, this population remains at high risk of both EC and GC.
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
In this study, we aimed to integrate the genetic alterations, protein expression profiles, transcriptomes Classification by consensus clustering using both RNA sequencing and proteomics revealed many similarities
- Ep 36 with Dr. Michel Bouvier
He was also the head of both my Master’s and Ph.D. thesis committees.
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A)
- Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells
Importantly, costimulation of both muscarinic receptors plus the TCR even led to reduced IL-2 expression
- Ep 145 with Dr John Janetzko
Both agreed on the importance of adaptability, as unexpected situations like the Covid-19 pandemic can The conversation concluded with both John and Yamina expressing a desire to support the academic community
- Session VII | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Furthermore, with the aim to analyse the biochemical properties of Remo, we performed immunoprecipitation We also aimed at identifying the signaling pathway that Remo is involved in. His research focuses on the relevance of aGPCRs in physiology and signaling using both in vitro and in
- Ep 142 with Dr Claudia Stäubert
Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect
- Ep 153 with Dr Jacek Mokrosiński
His research aimed at understanding molecular mechanism through which rare genetic variation may lead agreed, emphasizing the importance of mental preparation and embracing different social situations, both
- Ep 147 with Dr. Demet Araç
Both agreed that one should find work exciting and interesting, as life is too short to spend doing things
- Ep 144 with Dr Aurélien Rizk
They found it fascinating to integrate both fields and the potential it holds.