Search Results
115 items found for "Nobel Prize"
- Ep 109 with Dr. Katarina Nemec
used for functional screens with state-of-the-art microscopy and high throughput screening to explain novel
- Ep 65 with Dr. Sudarshan Rajagopal
His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the
- GPCR Retreat | Dr. GPCR Ecosystem
fellows, and principal investigators from academia and industry to discuss and debate existing and novel
- CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the
- From odor to oncology: non-canonical odorant receptors in cancer
Ultimately, this review discusses the potential development of novel therapeutic strategies targeting
- Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML
This offers a novel approach to quantitatively evaluate chemokine-receptor activation and antagonism
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
By examining the expression of known and novel marker genes, we validated the identity of these clusters
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
This approach has provided insight into novel drivers resulting from the widespread gene copy number
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
re-discovery of established cancer targets such as the LPA and mGlu receptor families, but also discovered novel
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
behavior, neurophysiology, GPCR signaling, and preclinical drug development, my lab will strive to develop novel
- Ep 54 with Dr. JoAnn Trejo
recognized expert on protease-activated receptors, particularly PAR1, and over the years she has discovered novel
- Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
In vitro results suggest that several of the novel small-molecule compounds could inhibit GHRH-induced
- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
Therefore, these antagonists may aid in the development of novel cancer therapeutics and patient-based
- Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions
receptors never walk alone, and additional mechanistic insights into the regulation of the GPCRs and the novel
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
This work elucidates a novel GPCR-integrin interaction in cancer invasion, highlighting its potential
- Ep 151 with Dr GPCR Board
a scientifc idea to a thriving Biotech focusing on Systems Biology & AI to accelerate the quest for novel recognized expert on protease-activated receptors, particularly PAR1, and over the years she has discovered novel
- Principles of Pharmacology in Drug Discovery II
., calcium, cAMP), and these new behaviors are being used to create novel GPCR therapies.
- Principles of Pharmacology in Drug Discovery II
., calcium, cAMP), and these new behaviors are being used to create novel GPCR therapies.
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
Results: Chidamide (tucidinostat), a novel histone deacetylase inhibitor, was found to have the greatest
- Ep 125 with Dr. Gregory Tall
Tall moved upstairs to conduct his postdoctoral work on heterotrimeric G proteins and the novel interactor
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
As therapeutic options are limited, novel targets, and agents for therapeutic intervention are urgently
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
Thus, our results identify LPAR-UCA1-let-7 axis as a novel avenue for targeted treatment strategies."
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
We aimed to identify GPCR-related gene (GPCRRG) signatures and develop a novel model to predict OV prognosis
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
While the detection of PAR2 may serve as a predictor for ovarian cancer, the novel Pc(4-4) compound may
- Session III | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
By leveraging self-cleavage and NTF release, the NRS technology offers a novel approach distinct from Our research aims to leverage this knowledge to identify novel pharmacological targets and contribute
- GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis
The possible biological mechanisms of GPR37 provide novel insights into the clinical diagnosis and treatment
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
Therefore, there is always an immense need to find promising and novel anti-cancer drug targets.