discovered the vast potential for GPCR-targeting drugs in treating a range of health conditions, from cancer

multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer

Chakit Arora, J Silvio Gutkind, and Francesco Raimondi for their work on The landscape of cancer-rewired protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor The landscape of cancer-rewired neutrophil biology: inflammation, resolution and beyond Exploring GPCR signaling pathway networks as cancer

platform clinically validated to guide treatment selection in patients with advanced haematological cancers

endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer

exclusivity on data related to GPCR implicated in immunoresistance, to develop first-in class innovative cancer

have been developed, with a focus on small molecules and monoclonal antibodies for the treatment of cancer

Autocrine Proteinase-Activated Receptor (PAR) signaling in PC3 prostate cancer cells. GPCRs in Immunology and Oncology The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer

receptor (A2AAR) have been considered promising agents to treat Parkinson's disease, inflammation, cancer

26 receptors identified in the previous study not detected in the current analysis, suggesting that variations also opens doors for exploring the roles of these receptors in various pathological states, including cancer

An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer Structure pulls off rare IPO, raising $161M 3-drug combo leads to 'unprecedented' response in pancreatic cancer

Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer activation of the adhesion receptor CD97 GPCR Activation and Signaling Biased Signaling in Mutated Variants guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer

receptors (aGPCRs)-a major family of GPCRs-play critical roles in the regulation of tissue development and cancer

GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.

For example, chemotherapy, a powerful standard approach to kill fast-growing cancer cells, has the drawback

scientists uncover “plant-like” behavior in important human cell regulator, opening up a new drug target for cancer spinal cord injury GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer

Staff Scientist, Computational Chemistry GPCR Activation and Signaling GPCR signalling: Yet another variant mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration

Nominated for Prestigious Prix Galien USA ‘Best Startup’ Award: Pioneering GPCR-Driven Immunotherapies in Cancer future directions Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer class C GPCR dimer mGlu5 Altered O-glycosylation of β1-adrenergic receptor N-terminal single-nucleotide variants

in the chemokine system can also contribute to various diseases, such as inflammatory conditions and cancer

from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers

Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer

signaling pathway, which is involved in embryonic development and is implicated in various types of cancer

A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer

GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer

GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled

correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer living cells Reviews, GPCRs, and more Restoring function to inactivating G protein-coupled receptor variants

intertwining roles of caveolin, oxytocin receptor, and the associated signalling pathways in prostate cancer