RGS5 expression in the triple-negative (TNBCs) and non-triple-negative breast cancers (Non-TNBCs) was The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs In contrast, in the context of breast cancer tissues, the role of RGS5 was completely disrupted. RGS5 expression was increased in the triple-negative breast cancer (TNBC) tissues and in the tumor blood Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer

CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Moreover, our findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer

University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

GPCRs in Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1

signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed in many solid breast cancers , and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays.

rationales, we studied the capacity of LP2 to inhibit the growth of patient-derived xenografts of colorectal cancer on an untreated tissue array demonstrated that the AT 2 R expression is reduced in human colorectal cancer specificity, safety and stability, warrant further evaluation of LP2's inhibitory potential of colorectal cancer . " Authors P Namsolleck , L de Vries , G N Moll Tags AT(2)R , Agonist , Angiotensin , Cancer , GPCR

Institute for Diabetes and Cancer, Helmholtz Centre Munich, Germany, 2. " About Anastasia Georgiadi "Head of Junior Group Endocrine Pharmacology, Institute of Diabetes and Cancer Professional Background Since 2021 Group Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2018 - 2021 Project Team Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Munich 2015 - 2018 Postdoctoral fellow, Department of Adipose Tissue Biology, Institute for Diabetes and Cancer

Potent inhibitors of ADO signaling are currently being tested in cancer patients, including in randomized immunologist, Dr Stagg is recognized for having identified the adenosine-producing enzyme CD73 as a new cancer John Stagg on the web University of Montréal Québec Cancer Consortium The University of Montreal Hospital

Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet Methods: Immunohistochemistry and lung cancer tissue microarray were used to verify the expression of role of RGS20 as a promising novel molecular marker and a target for future targeted therapies in lung cancer

the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis and cancer SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous High expression of SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous

and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and cancer Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

PDF Program HERE < Back to Full Agenda Posters Interrogating The Role Of CELSR1 (ADGRC1) In Breast Cancer Caroline Formstone Abstract "Breast cancer is the most common form of cancer amongst women. Recent studies identify CELSR1, a key PCP gene, as a novel biomarker for early-stage breast cancer. The impact of CELSR1 on cancer progression, however, is unclear. Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas

2022 Abstract Due to its high metastatic potential, malignant melanoma is one of the deadliest skin cancers In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse

multifunctional adhesion GPCR involved in diverse biological processes ranging from development to cancer Despite its important role in cancer, its mechanism of action or signaling is not completely understood

Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA 5 O'Neal Comprehensive Cancer Van Meir pursued postdoctoral work at the Ludwig Institute for Cancer Research in San Diego and joined Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic translate these novel agents to testing in clinical trials with the hope to develop novel medicines for cancer

control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation, and cancer

protein-coupled receptors (GPCRs), enhancing proliferation, adhesion, and migration in many types of cancer Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell

Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations

Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative repurposing statins as Ras oncogene inhibitors and the failure of using prenyltransferase inhibitors in cancer

Published date October 23, 2023 Abstract Glioblastoma multiforme (GBM) is one of the most aggressive cancers We used The Cancer Genome Atlas (TCGA) GBM genomic dataset to identify differentially expressed genes

Weill Cornell Graduate School of Medical Sciences in New York City, studying epigenetic changes in cancer

Sabbagh undertook post-doctoral fellowships at the Ontario Cancer Institute and the University of Toronto projects aimed on drug discovery of small molecules for the treatment of inflammatory disorders and cancer Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC the development of innovative treatments for a range of diseases, including psychiatric disorders and cancer

However, the role of β2-AR in oral cancer is not well identified. Kumar Mohanty, Rajender Singh, Vijay Kumar, Uma Shankar Singh, Rakesh Kumar Singh Tags GPCR; OSCC; Oral cancer

Scientist at GPCR Therapeutics, Inc , a drug discovery company focused on targeting GPCR heteromers in cancer

Patients' data on HCC were sourced from the Liver Hepatocellular Carcinoma-Japan (LIRI-JP) and The Cancer dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration levels and genetic variations immunotherapy and common antitumor drugs was predicted via the database Genomics of Drug Sensitivity in Cancer

His research experience includes phylogenetics and cancer epigenetics.

His undergraduate thesis work on studying the biochemical mechanisms of flavonoids in cancer using nuclear

She is also the Associate Director of the City of Hope Comprehensive Cancer Center. Dr.