However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic data shows that, in TNBC, it is not universally true that kisspeptin/KISS1R stimulate migration or pro-metastatic

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mediates desensitization and internalization of G protein-coupled receptors (GPCRs) and it participates in inflammatory

Previous research showed that activation of Gq/11 proteins by G-protein coupled receptors has pro-nociceptive

which work in a team with canonical chemokine receptor to drive regulated immunological responses and inflammatory Volpe et al. 2012); it dampens the inflammatory response when needed (C. A. H.

Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.

Graeme Milligan and their colleagues research on Pro-phagocytic function and structural basis of GPR84 cells in the vinegar fly Drosophila melanogaster Structural and Molecular Insights into GPCR Function Pro-phagocytic

Since many inflammatory diseases are driven by inappropriate recruitment of monocytes into tissues, CCR2 has been described as the master controller of inflammatory pathology and is considered a valuable drug target for a number of inflammatory diseases including atherosclerosis, scleroderma, multiple sclerosis OB-004 showed powerful efficacy, achieving full blockade of monocyte recruitment in response to the inflammatory

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

HTR1E stable cells with NF-α1/CPE increased pERK 1/2 and pCREB levels which prevented a decrease in pro-survival

in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory

Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory

Endocrinology, and Taste Cyclic adenosine monophosphate critically modulates cardiac GLP-1 receptor's anti-inflammatory

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growth, we show that PI3K inhibition and depletion of GRK2 expression produced a similar ablation of pro-proliferative

induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages

Cardiology, Endocrinology, and Taste The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory

shining light on signaling pathways GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage

downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory

adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages

metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages

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Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses

PMID: 38412860 GPR133 is hypomethylated and upregulated in decidual macrophages in recurrent spontaneous

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showcases significant data updates from Kisqali®, iptacopan and Scemblix® at SABCS and ASH Research reveals pro-phagocytic