The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

California in San Francisco to continue his training as a postdoctoral researcher where he used structural models

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

He adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled

transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models

His research group uses a combination of pharmacological investigations and mathematical modeling to

Signaling Trafficking Metabolism Structure and Bioinformatics Health and Disease Immunology Nervous system Model

the understanding of how an orphan GPCR exerts its effects both in vitro (cell culture and ex vivo models

computational structural biology tools and rational drug design approaches, ranging from molecular modeling

Dominique Schols , Patrick Verschueren , Mette M Rosenkilde , Pedro Elias Marques , Sofie Struyf , Paul Proost

against inflammatory diseases and blockade of ITA production enhances antitumor immunity in preclinical models

I work with invertebrate animal models (mainly D. melanogaster) and in vitro techniques to pick apart adhesion GPCRs, and extends to the development of novel screening approaches to identify pharmacological modulators

His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems,

However, whether inflammation resolution is modulated by extracellular vesicles (EVs) and vesicular mediators Administration of efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase

the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse models A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models

GPR50 could protect against breast cancer development and decrease tumor growth in a xenograft mouse model

approaches to explore the functional and therapeutic impacts of CB2 engagement on VAT ILC2s in a T2DM model

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models Slosky characterized a new class of β-arrestin biased allosteric modulators (BAMs) for the neurotensin Critically, these ligands reduce addiction-associated behaviors in animal models without the side effects

laboratory is to understand the physiological consequences of NMDA receptor deficiency using genetic mouse models

an mTOR inhibitor remarkably impaired tumor growth and extended mouse survival in an AML xenograft model

These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington

For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models

GPCR Title: Modeling Cardiac Fibrosis in a Dish: Combining hIPSC-Derived Fibroblasts and FRET Biosensors

critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells and mouse models

proteogenomic characterization of natural killer/T-cell lymphoma (NKTCL), a representative disease model Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated

Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1