Beaulieu’s research is aimed at understanding how cellular and molecular mechanisms regulated by psychoactive Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR) The pathogenesis of EOC can be regulated by many local factors, including neuropeptides, through an autocrine Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression

CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate While CXCR4 couples to G proteins and directly promotes cell migration, ACKR3 is G protein-independent and scavenges CXCL12 to regulate extracellular chemokine levels and maintain CXCR4 responsiveness, thereby The dynamic properties of ACKR3 may underly its inability to form productive interactions with G proteins that would drive canonical GPCR signaling."

She identified the molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors by protein kinase C. Robert Lefkowitz , which led to the finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling in endosomes by forming a megaplex. Funded by a Wellcome Trust Seed Award, she investigated biased and compartmentalized G protein signaling

proteins by G protein-coupled receptors (GPCRs). for agonist-mediated activation of G proteins. changes in G protein structure. Some of these studies resolved a major question regarding the signaling differences in G protein splice We demonstrated that Galpha-s(l), but not Galpha-s(s), regulates extracellularly regulated kinases (ERK

Our working hypothesis is that distinct CELSR1 protein isoforms differentially regulate tissue adhesiveness are members of group VII of the adhesion G protein-coupled receptor (aGPCR) family. MAGI3, a PDZ-containing scaffolding protein is known to downregulate WNT signaling by interacting with Kordon Abstract "Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved Anxiety and memory function were tested using both male and female mice at 5-6 month of age.

12, 2024 Loss of cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure Read More September 5, 2024 The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH Signaling Read More Read more Adhesion GPCR articles 2024 Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology Read More September 6, 2023 opnMe GPCR Route 66+ project Read More October 1, 2022 GPCRs: Signal Transduction Read More GPCR

in molecular pharmacology and his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled receptor (GPCR) responses, a class of receptors involved in many, if not all, physiological He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor trafficking and signalling, useful for drug discovery programs. His research program also studies the allosteric, biased signalling regulation of GPCR and has contributed

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug modulators of D2R signaling and explores the potential usefulness of beta-arrestins for the development regulation of protein synthesis as a potential downstream effector of the action of mood stabilizers

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling endosomes. Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and

in Adhesion G Protein-Coupled Receptors Andrew Dates Discriminating between the extracellular scaffolding and G protein signaling roles of GPR56/ADGRG1 via the characterization of a non-cleavable point mutant It has been suggested that the TA can regulate receptor signaling without coming out of the GAIN domain As an undergraduate, he studied opioid receptor trafficking and G protein conformational dynamics in protein signaling roles of GPR56/ADGRG1 via the characterization of a non-cleavable point mutant knock-in

Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Finally, we identified that G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-store-operated Ca2+ (SOC) signaling was crucial for enhancive cytosolic Ca2+ and PEDV G protein-coupled receptor (GPCR)-phospholipase C (PLC)-inositol trisphosphate receptor (IP3R)-SOC signaling Tags calcium signaling , infection , interleukin-8 , porcine epidemic diarrhea virus , therapy .

University in Philadelphia, PA, for his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling. His laboratory is interested in understanding the mechanisms that govern spatial and temporal regulation of GPCR signaling by -arrestins and post-translational modifications (PTMs), such as phosphorylation His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged

< GPCR News < GPCRs in Oncology and Immunology Aberrant hormone receptors regulate a wide spectrum of endocrine tumors Published date September 23, 2024 Abstract "Aberrant G-protein coupled receptor (GPCR The aim of this review is to show that the regulation of endocrine tumours by aberrant GPCR is not restricted in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling angiostatic activity Published date February 2, 2024 Abstract " Background: Interferon-γ-inducible protein protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3). in calcium mobilization assays and through quantification of phosphorylated extracellular signal-regulated kinase-1/2 (ERK1/2) and protein kinase B/Akt.

Lab LinkedIn Characterization of Phenotypes Associated with GPR110 Deletion Hee-Yong Kim Abstract "G-protein Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing The change in protein expression of key proteins including VEGFA is associated with the abnormal renal at NIAAA, NIH" Hee-Yong Kim on the web NIH The Adhesion GPCR Cupidon Regulates Mating In The Closest In this study, we report the discovery of an adhesion GPCR, named Cupidon, that regulates the switch

non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. experiments verified whether overexpression of RGS20 affect the proliferation and autophagy of NSCLC through regulating Remarkably, inhibiting Hippo signaling with GA-017 promoted cell proliferation and activated autophagy

inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein Antagonizing NPY1R and/or NPY5R in hypoxia compared to normoxia more greatly reduced MAPK signaling, In human breast tumor tissue, we show via immunofluorescence that NPY5R protein levels and colocalization with hypoxia correlate with advanced cancer, and NPY1R protein correlates with adverse outcomes.

protein-coupled receptors (GPCR). Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding , signal transduction . in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology Identification of a G-protein coupled receptor-related G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency G protein-coupled receptors that are stimulated upon increased extracellular acidity. </p> Taken together, in the acute setting of oxalate-induced nephropathy, the lack of the proton-activated Krudewig , Giovanni Pellegrini , Nicole Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Understanding the signaling pathways involved in cancer progression is essential for the discovery of The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and understood and are variable among cancer types; however, AC overactivation, along with that of downstream regulators In addition, we highlight inhibitors of AC-related signaling that are currently under investigation, protein , GPCR , Hallmarks of Cancer , cAMP signaling .

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled Despite its important role in cancer, its mechanism of action or signaling is not completely understood , growth factors, and inflammation signaling pathways. GPR56 signaling and mesenchymal transition."

was these studies and subsequent postdoctoral work that led to Nick's interest in peptide messengers regulating appetite, metabolism, and the immune system, and the molecular mechanisms underlying the signaling and regulation of their GPCRs. University of Nottingham in 2006, where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor kinetics, signaling, and trafficking and on using novel imaging techniques,

Keith Parker to elucidate the role of steroidogenesis in regulating sexual determination and adrenal With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling , they are exciting tools for linking distinct signaling pathways with their physiological effects and

protein-coupled receptors (GPCRs) by Prof. NIDDK) - NIH, USA as a postdoctoral fellow and trained on understanding the physiological role of GPCR signaling GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues regulating Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

Slosky’s research is focused on understanding how neuropeptide G protein-coupled receptors (GPCRs) regulate Marc G. Caron at Duke University. Dr. These ligands stimulate receptor β-arrestin recruitment without activating canonical G protein signaling Because BAMs engage less well-conserved allosteric sites and exert pathway-specific effects on receptor signaling , they are exciting tools for linking distinct signaling pathways with their physiological effects and

We investigated the prognostic values of the guanine nucleotide-binding protein G(i) alpha subunit (GNAI Notable pathways included "Cytoskeleton remodeling regulation of actin cytoskeleton organization by the Sanskriti Dey , Sachin Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy , molecular biomarker , prognosis , signaling pathway in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling