August 8, 2024 Dynamic nature of G-protein coupled receptors Septerna Secures $150 Million in Series B

Contribution to Asymmetric Mating Between Two Sibling Nematode Species: Bursaphelenchus xylophilus and B.

Reeves KC, Shah N, Muñoz B, Atwood BK.

Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P2 Lipids.

agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional reporter, G protein activation and B-arrestin

GPCR Binders, Drugs, and more Altered signaling at the PTH receptor via modified agonist contacts with Alterations in mouse visceral adipose tissue mRNA expression of islet G-protein-coupled receptor ligands Structural and Molecular Insights into GPCR Function Computational investigation of functional water

inactive states of CCR5, it becomes evident that there are four distinct pathways through which structural alterations ultimately driving receptor activation: a) Route 1 - hydrogen bonding to Y2516.51 by CCL3 or CCL5; b)

independent endosomal G protein activation by the vasopressin type 2 receptor GPCR Binders, Drugs, and more Altered bioinformatics studies of bacterial outer membrane beta-barrel transporters and their AlphaFold2 predicted water-soluble

The human islet GPCRome is not a static entity, but one that is altered under pathophysiological conditions We have also considered the likely outcomes on islet function that the altered GPCR expression status possible impact that adipokines, secreted from expanded fat depots, could have at those GPCRs showing altered

Alterations in gene expression appear in pathways related to primary cilia (PC). Inhibition of this pathway rescues the alterations in PC morphology and mitochondrial dysfunction.

We demonstrate in male and female rats that GABAB receptors receptors alter Pr, whereas 5-HT1B receptors sophisticated hippocampal output filter that itself is modulated by colocalized GABAB receptors which alter GABAB receptors alter Pr leaving synaptic properties unchanged, while 5-HT1B receptors fundamentally Co-activation of these receptors allows synaptic integration because of convergence of GABAB receptor alteration on Ca2+ and the effect of this altered Ca2+ signal on 5-HT1B receptor signaling.

Interestingly, these parameters are altered in cholesterol-depleted cells and the receptor exhibits dynamic modulatory role of the membrane environment on the organization and dynamics of GPCRs in diseases caused by altered

GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor Influence of the Water and Interactions of the GPR40 Protein with the Lipid Membrane and the Solvent: Rigid versus Flexible Water

Luisa Salter-Cid , Dr. Omar Nadeem and Dr.

September 2022 "RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter

modulators of G protein-coupled-receptors (GPCRs), mechanistic understanding of how these modulators alter

This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface, alterations

The absence of VLGR1 in tissues and cells derived from VLGR1-deficient mouse models resulted in alterations

with both Ser2777.42 and His2787.43, 2 only transiently contacts His2787.43, which can be direct or water-mediated

outcomes in various primary and clonal cell systems, with even small changes in amino acid sequence altering

GPCR Activation and Signaling Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome Antagonistic interactions between odorants alter human odor perception.

dietary restriction, those related to insulin signaling and the AMPK and TOR pathways, and those that alter

substances at the serotonin receptor 5-HT2A R "Serotonergic psychedelics are substances that induce alterations

In conclusion, 10μM THC and CBD altered the differentiation of HC11 cells, in part via the CB2 receptor

Circulating catecholamines (norepinephrine and epinephrine) and aldosterone elevations are among the salient alterations

The availability of polar atoms for interactions in such cavities can be assessed by water molecules

However, GnIH peptides did not alter NFAT-RE-luc activity and ERK phosphorylation levels.

Nonetheless, we determined that mGlu5a internalization was not altered upon the loss of cPKCs or nPKCs