Search Results
101 items found for "SCI-induced immunodeficiency syndrome"
- Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
</p> Taken together, in the acute setting of oxalate-induced nephropathy, the lack of the proton-activated
- Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone
Treatment with the porcupine inhibitor LGK974, which blocks Wnt signaling broadly, induced partial resorption
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
The TNF-α-induced protein 8-like (TIPE or TNFAIP8L) family of proteins are newly described pilot proteins
- Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans
- Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway
Treatment with KS-133, a VIPR2-selective antagonist peptide, significantly inhibited VIP-induced cell
- Classified News | Dr. GPCR Ecosystem
cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced Read More December 1, 2024 Intranasal delivery of liposome encapsulated flavonoids ameliorates l-DOPA induced
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition.
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
CD11c+ dendritic cells, and CD4+ T cell infiltration into the experimental autoimmune encephalomyelitis-induced
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
autonomic nervous system receptors Published date September 7, 2023 Abstract "Background: The Long-COVID syndrome
- Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions
) and phosphorylate their intracellular parts, which eventually blocks signal propagation and often induces
- Trainee Symposium II
Master's degree in Pharmacology at Minia University, focusing on hydrogen sulfide's role in hypertension-induced
- Ep 154 with Dr Badr Sokrat
identified the challenges scientists, particularly students and researchers, face, such as imposter syndrome Yamina and Badr agreed on the importance of individuals struggling with imposter syndrome learning to
- Ep 107 with Dr. Roger Sunahara
kinases (ERK), and that this long isoform is tied to a devastating blood disorder, myelodysplastic syndrome
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Ligand-induced GPR110 signaling stimulates neurogenesis and synaptogenesis during development, and the absence of the ligand-induced signaling causes object recognition and spatial memory deficits in adulthood RNAseq data indicated significantly impaired developmental gene expression for neuronal differentiation
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
, GPCR , Group 2 innate lymphoid cell , HES , High-affinity Fc receptor for IgE , Hypereosinophilic syndrome
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator
- Abstract Submission Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Funding source Oral presentations Extended deadline: August 1st Speaker name indicated in bold and underlined Indicate abstract category on top left corner (up to 2 categories max) Abstract categories Signaling Biosensors and Molecular Tools Biomarkers Poster presentations Deadline: August 1 The presenter's name is indicated
- Ep 96 with R. Scott Struthers
pharmaceutical company focused on the discovery and development of novel radiotherapeutics for oncology indications
- Ep 79 with Dr. Graeme Milligan
2015) which discovers novel therapeutics for metabolic diseases including Type 2 Diabetes and other indications
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
These data collectively indicate that optimal glycosaminoglycan interactions and dampened receptor activity
- GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
Diagnostic indicators and treatment objectives for CRC are urgently needed.
- Chemoattractant receptor signaling in humoral immunity
Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery
- Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation
in vitro validation Published date July 27, 2024 Abstract "Genetic heterogeneity in ovarian cancer indicates
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Our results indicate that two-thirds of tested cores exhibit clinically significant expression of at
- Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML
The study results indicate chemokines interact with hCCR3 at low concentrations, and reversible hCCR3
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
We also observed PTX-dependent TNT biogenesis in response to lysophosphatidic acid (LPA), indicative
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
Kinome analyses and validation of elected kinase inhibition indicated that LP2-mediated AT 2 R stimulation