Indeed, ACKRs behave as scavenging “decoys” in order to either limit chemokines spatial availability a phenomenon which is likely to be mediated by changes in the cell motility machinery with receptor-specific

GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology We are also seeking sponsors to support this exciting event that unites scientists worldwide to explore Interested in sponsoring? Please email us at Hello@DrGPCR.com. Engine at ENDO 2024 The Promise of Oxytocin: Novel Approaches for Targeting Oxytocin Receptors in Autism Spectrum

throughout many species. isoform-specific agonist/antagonist compounds. Of course, there is the famous parade popularized by the James Bond movie Spectre. The meat on a rotating spit with its bright red/orange chili-based marinade (spicy but not hot) catches , for understanding tissue distribution of alternatively spliced genes.

The more we know about the pathology of diseases, the more complicated it is to modulate them by a specific ERK signaling, tightly regulated through feedback mechanisms and spatial localisation within the cell utilising advanced assay technologies, researchers can identify novel drugs that selectively modulate this specific Spatiotemporal regulation of the p42/p44 MAPK pathway. Biology of the Cell, 93(1‐2), 71-79.

And don’t miss our job opportunity spotlight for a Principal Scientist in In Vitro Pharmacology! We are also seeking sponsors to support this exciting event, which unites scientists worldwide to explore If you're interested in sponsoring, please email us at Hello@DrGPCR.com.

high-resolution, dynamic view of GPCR activation, scientists can better tackle diseases by targeting specific

A special episode with our board, meet Drs. Maria Waldhoer, JoAnn Trejo, and Anne Marie Quinn. Stay tuned We are also looking for sponsors to help support this fabulous event that brings together Please reply to this email if you'd like to sponsor this event. involved in the resistance of Rhopalosiphum padi to pyrethroids Discovering allatostatin type-C receptor specific , GPCRs, and more Molecular adaptations in response to exercise training are associated with tissue-specific

., Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate

Only five spots left! Team Registrations are also open!  GPCR Matchmaking Did you check out our first job opportunity spotlight for a Principal Scientist In Vitro Alzheimer's disease Parenting behaviors in mice: Olfactory mechanisms and features in models of autism spectrum chimeric peptide ligand for NanoBiT complementation binding assays Generation of a deep mouse brain spectral

17 out of the 25 spots have been filled! Team Registrations are also available!  GPCR Matchmaking Did you check out our first job opportunity spotlight for a Principal Scientist In Characterization of myoinhibitory peptide signaling system and its implication in larval metamorphosis and spawning

Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into G protein coupling specificity 11 out of the 25 spots have been filled! Team Registrations are also available! It doesn’t have to be a complete poster, just a few slides to spark the conversation. entities Structural and Molecular Insights into GPCR Function Molecular insights into G protein coupling specificity

April is the month of DNA Day, a special day commemorating the discovery of the DNA double helix structure This intersection of genomics and GPCR research sparked a new era of a comprehensive understanding of This variation is due to factors such as alternative splicing, gene duplications, and variability in

3 out of the 25 spots have been filled! Team Registrations are also available! It doesn’t have to be a complete poster, just a few slides to spark the conversation.

Reserve your spot today. We are pleased to announce five full scholarship opportunities for Dr. If you have a few minutes to spare and have participated in our symposiums, we would appreciate it if interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics simulations Preassembly of specific companies are using AI to design drugs GPCR Therapeutics Announces Publication in PNAS Using Cutting Edge Spectroscopy

ligand, as well as interactions with signaling molecules like G proteins, can selectively stabilize specific The initial demonstration of spontaneous or "constitutive" receptor activity was reported for the β2- target large and diffuse binding sites activated by peptides or proteins, and the disruption of natural spatial Depending on the specific functional outcome measured (e.g. activation, interaction with accessory proteins They can be compared to molecular rheostats, capable of sampling a spectrum of conformations with relatively

If you have a few minutes to spare and have participated in our symposiums, we would appreciate it if

GPCR Symposia We extend our heartfelt thanks to all speakers and participants for making our recent Dr

We are pleased to confirm the participation of a great lineup of speakers, namely Drs.  of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91 Specific Chemicals Activate G Protein-Coupled Receptors GPCRs in Neuroscience A M1 muscarinic acetylcholine receptor-specific Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy inflammation and defense Methods & Updates in GPCR Research Improved green and red GRAB sensors for monitoring spatiotemporal

We are delighted to confirm the participation of esteemed speakers such as Drs. 

The localization of GPCRs to specific intracellular compartments dictates the spatial and temporal dynamics Showing that this spatially biased signaling through arrestins can influence transcriptional responses As the mechanisms underlying spatial bias in GPCR signaling involve both temporal and spatial components Therefore, targeting specific intracellular compartments and signaling pathways associated with GPCRs This may involve the development of specialized delivery vehicles, such as nanoparticles or liposomes

We are delighted to confirm the participation of esteemed speakers such as Drs. protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegan Species-Specific Duplicated FMRFaR-like Gene A62 Regulates Spontaneous Locomotion in Apolygus lucorum Whole Brain Mapping

Confirmed speakers include Drs.  Classified GPCR News from February 12th to 18th, 2024 GPCR Activation and Signaling Fine-tuning activation specificity cortical gene expression after antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing GAPs, neddylation and GPCR ligand binding GPCRs in Oncology and Immunology Neutrophils are itching to specialize Biomedical Investigator Takes Aim at Cracking Cellular Communication Code Aelis Farma will be at Bio Europe Spring

Confirmed speakers include Drs.  Biotechnology to Showcase GPCR Progress at 2024 OBIO Investment Summit BioAge raises $170M as obesity spotlight

Dimitrios Stamou, et al. for their work on the Molecular mechanism of GPCR spatial organization at the Confirmed speakers include Drs. the constitutively active orphan G protein-coupled receptor GPR52 Endosome positioning coordinates spatially insights into membrane adenylyl cyclases, initiators of cAMP signaling Molecular mechanism of GPCR spatial

Congratulations to Domain Therapeutics for being awarded the RHU SPRINT consortium grant. Confirmed speakers include Drs. GPCR University We're thrilled to share that all spots for the Applying Pharmacology to Drug Discovery We'll let you know if any spots become available. Dr. articles to our community, keep you updated with GPCR papers, receive support and network with GPCR specialists

Due to popular demand, we have opened additional spots. If you'd like to join colleagues and Dr. Only three spots remain. GPCR University and secure your spot before registration ends on February 1, 2024. Dr. Senior Researcher in Structural Biology Post-Doctoral Fellow Postdoctoral Fellow Research Laboratory Specialist

Hurry and secure your spot today! Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members Only 9 Spots GPCR University and save your spot today! Dr. signaling linked to nutrient load and obesity GPCRs in Neuroscience The Na+ leak channel NALCN controls spontaneous Senior Researcher in Structural Biology NEW Post-Doctoral Fellow Postdoctoral Fellow Research Laboratory Specialist

Only ten spots remain. Hurry and secure your spot today! GPCR University and save your spot today! removing key electrostatic interactions Industry News Domain Therapeutics strengthens leadership team to spearhead Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellow NEW Research Laboratory Specialist