Activation and Signaling Structure-guided engineering of biased-agonism in the human niacin receptor via single neurological and psychiatric disorders: An in silico approach Opioid modulation of prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation progression in MCF-7 cells Methods & Updates in GPCR Research Cryo-electron microscopy for GPCR research Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory Operations - Single-molecule

Interestingly, olfactory neurons gene expression is very peculiar, and each neuron expresses a single OR gene however, ectopic ORs expression is unlikely to be modulated by this tight mechanism with transcriptomic analysis revealing that while the majority of cancer cells express multiple ORs, tumor cells associated with the nervous system express a single OR gene type (Kalra S. et. al 2020). In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and

August 2022 "GPCRs in Medicinal Chemistry Event 8th RSC / SCI symposium on GPCRs in Medicinal Chemistry Dates Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links Registration closing dates: 6th September – registration against invoice (bank transfers): Tuesday, 6th September 30th September – online registration (card payments)" Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany. Hybrid meeting. "Dear Sir or Madam, dear Colleagues, It gives me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled receptors (GPCRs) in Lübeck. GPCRs are involved in a variety of physiological and pathophysiological processes. So far, numerous therapeutics targeting GPCRs have been developed, with a focus on small molecules and monoclonal antibodies for the treatment of cancer, infections, metabolic disorders or inflammatory diseases. Recently, functional autoantibodies targeting GPCRs have been associated with various disease-specific manifestations, highlighting a potential new area for therapeutic intervention. Therefore, the aim of this symposium is to bring together the current knowledge on the role of autoantibodies targeting GPCRs in various diseases, such as cardiovascular diseases, renal diseases, autoimmune diseases such as systemic sclerosis or systemic lupus erythematosus. In addition, one aim is to bring together the mode of action of autoantibodies in immune regulation and pathogenesis." Read more at the source #DrGPCR #GPCR #IndustryNews

Discovery on Target (DOT) highlights advances in current and emerging “hot” targets and technologies, as well

August 2022 "WELCOME 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for a joint meeting in Leipzig. Four of the biggest European networks on GPCR research (COST Actions Adher’n Rise and ERNEST plus DFG-funded SFB1423 and FOR2372) have joined forces to organize an international meeting, which will take place from 26th-29th September 2022 in the beautiful city of Leipzig in Germany. We aim to connect renowned international experts of the field with early career ‘rising stars’. The event will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid social life." Read more at the source #DrGPCR #GPCR #IndustryNews

August 2022 "We are happy to announce you our 2nd IRN i-GPCRnet meeting that will be held at the University of Wurzburg (Germany) from september 30th to october 1rst." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics optimized approach of combining the data derived from steered molecular dynamics simulations and the Bell-Evans

perspectives of CXCR4 antagonists for disease therapy GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic profiling highlights cell proliferation in the progression of experimental pulmonary hypertension in stress mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific behavioral and transcriptomic Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells

Methods & Updates in GPCR Research The Road to Quantitative Lipid Biochemistry in Living Cells. Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression into GPCR Function Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FREE Symposium - IPI Surfacing (June 15, 2023) Training School on “Cell-based assays to study Adhesion Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs Convergent Research - Senior Scientist, Cell-Based

The ONE-GO biosensors, designed in a single vector, incorporate a G protein tagged with a YFP acceptor Front Cell Dev Biol, 2021. 9: p. 611443. 3.      Cell, 2020. 182(3): p. 770-785.e16. 4.      Galés, C., et al., Real-time monitoring of receptor and G-protein interactions in living cells.  Goyet, E., et al., Fast and high resolution single-cell BRET imaging. 

Redundancy can be exemplified by the tumor infiltration of Treg cells which can be driven directly by receptors (CCR4, CCR5, CCR6, CCR7, and CXCR3) and so inhibition of this process through blockade of a single This redundancy can be seen as problematic in drug discovery as blocking a single receptor might not surface (Mack et al. 1998), CCR3 is partially restored to the cell surface and partially targeted to Moreover, it is difficult to demonstrate clinical efficacy with a specific antagonist to a single receptor

Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma Single-molecule enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor Comparative transcriptomic combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Methods & Updates in GPCR Research Modulating signalling prediction using a protein language model Reviews, GPCRs, and more Potential of olfactory neuroepithelial cells

., 1950 ), also called Duffy-antigen/receptor for chemokines, or DARC ( Novitzky-Basso and Rot, 2012 Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Additionally, ACKR1 expression characterizes venular endothelial cells (ECs) ( Pruenster et al., 2009 This well-established, distinctive pattern of cell expression has been directly challenged by a publication and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 on hematopoietic stem cells

Monserrat Avila-Zozaya , our incredible contributor, for her fantastic article on Profiling Immune Cell and Platelet Transcriptomes , and we want to wish her the best of luck on her talk today at the 11th Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell receptors GPCRs in Cardiology, Endocrinology, and Taste Latrophilin-2 Deletion in Cardiomyocyte Disrupts Cell

March 2022 " Geneva, Switzerland, March 7, 2022 – Addex Therapeutics (SIX: ADXN, Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, announced today that it will issue its full-year 2021 financial results on Thursday, March 10, 2022. Tim Dyer , CEO, Roger Mills , CMO and Robert Lütjens , Head of Discovery Biology, will provide a business update and review its pipeline during a teleconference and webcast for investors, analysts and media at 16:00 CET (15:00 GMT / 10:00 EST / 07:00 PST) the same day. " Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Activation and Signaling Single transmembrane GPCR modulating proteins: neither single nor simple GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells zoominar (June 22, 2023) NEW Meet Inoviem Scientific Team (June 19 - 23, 2023) Training School on “Cell-based

Vladimir Katanaev and colleagues identified compromised GPCR signaling in cancer cells using improved disease by targeting adhesion G protein-coupled receptor F1 ( Adgrf1) GPCR Activation and Signaling Single-molecule HTR1B-β-Arrestin1 Complex in Stress and Anxiety Disorders GPCRs in Oncology and Immunology Exacerbating effects of single-dose S1P1 signaling axis Methods & Updates in GPCR Research Magnetic Liposomes Infused with GPCR-Expressing Cell Sewage Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers in live cells November 5 - 7, 2024 | 16th Annual PEGS Europe   September 18, 2024 | FREE Webinar - The value of GPCR cell-based

October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway Through its control of synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling Neural PKA signaling is regulated by afferent and peripheral efferent signals that link specific neural cell

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients Methods & Updates in GPCR Research Illuminating the brain-genetically encoded single wavelength fluorescent 15, 2023) GPCRs in drug discovery: challenges & solutions (June 19 - 23, 2023) Training School on “Cell-based

ERK signaling, tightly regulated through feedback mechanisms and spatial localisation within the cell Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone Cell Receptor-Mediated Gene Expression. Cells, 10(10), 2509. Volmat, V., & Pouysségur, J. (2001). Biology of the Cell, 93(1‐2), 71-79. Wei, H., Ahn, S., Shenoy, S. K., Karnik, S.

Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Minor Effects on Cardiac Hypertrophy Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Spliceosome mutations are associated

Fibroblasts are a key effector cell in SSc. Promising nuclear receptors as key regulators of transcriptional programmes will be introduced as well Fibroblasts from SSc patients exhibit a specific signalling and reactivate developmental pathways and stem cell

RNA sequencing of intestinal epithelial cells responding to butyrate and secondary bile acids in combination discovered a unique transcriptional program involving multiple pathways that converge on P-gp induction Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the

wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing β-catenin stability and transcriptional A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues , exhibits low levels of β-catenin and a markedly reduced transcriptional activity following PAR4 activation Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular Modulating a single function of a specific aGPCR isoform while affecting no other function and no other

via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment. GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells Transcriptome profiling of male and female Ascaris lumbricoides reproductive tissues. Expansion To Enable Site-Specific Bioorthogonal Labeling of Functional G Protein-Coupled Receptors in Live Cells