(IELs) are thought to calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic anti-inflammatory actions of GLP-1RAs require the gut IEL GLP-1R to selectively restrain local and systemic GLP-1R activation in gut IELs to modulation of microbiota composition and control of intestinal and systemic

winners of its Transforming Cancer Therapeutics grant, which focuses on developing life-changing cancer treatments Sleep-Deprived Healthy Volunteers Cumulus raising $50M, spinning GPR68 small molecules into GIO New treatments , Endocrinology, and Taste CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic

pathways via MADD, a Rab11A effector that activates Rab27B Targeting of insulin receptor endocytosis as a treatment TRPV4 to suppress astrocyte activation and to relieve neuropathic pain GPCRs in Oncology and Immunology Systems Drug Application in Japan for Daridorexant (ACT-541468), a Dual Orexin Receptor Antagonist for the Treatment

Structural genomics of the human dopamine receptor system Structural Insights into Molecular Recognition Quarter 2023 Structure Therapeutics Initiates Phase 2a Study of Oral GLP-1 agonist GSBR-1290 for the Treatment

Although less characterized, canonical chemokine receptor systems have been also shown to not only directly However, it is important to note that this scavenging role does not occur in all chemokine receptor systems In monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2, and CCR5 switch

2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic Finally, we conducted epinephrine tolerance test to investigate systemic glycemic excursions to counterregulatory

Therefore, their comprehension is essential for developing new treatments for these disorders and advancing our understanding of the brain and nervous system.

small molecules against cannabinoid 2 receptor (CB2R) Ketone bodies as chemical signals for the immune system Achieves Milestone: Randomisation Concludes in Largest-Ever Phase 2b Clinical Trial for Cannabis Addiction Treatment

and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target for the treatment Internal and external modulation factors of the orexin system (REVIEW).

more ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system Announces Positive Initial Findings At Endo 2024 For Atumelnant In Two Ongoing, Open-Label Studies For The Treatment

pluripotent stem cell-derived nociceptive-like neurons Characterization of myoinhibitory peptide signaling system Aelis Farma announces the Last Patient, Last Visit in its clinical phase 2b trial with AEF0117 for the treatment

powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems Initiation of Phase 1 Clinical Trial with SEP-786, a Novel Oral Small Molecule PTH1R Agonist for the Treatment

focused on the development and commercialization of novel medicines for patients with central nervous system

Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems

Latrophilins are highly conserved Adhesion GPCRs playing essential roles in the mammalian nervous system Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the C. elegans nervous system

al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology for the treatment , Andrew Lawrence , et al. for their remarkable analysis on Targeting muscarinic receptors for the treatment neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment family: Opportunities and challenges Class B1 GPCRs: insights into multireceptor pharmacology for the treatment receptor as a therapeutic target for substance use disorders Targeting muscarinic receptors for the treatment

powerful applications of new cellular assays to determine GPCR ligand behavior in different functional systems Initiation of Phase 1 Clinical Trial with SEP-786, a Novel Oral Small Molecule PTH1R Agonist for the Treatment

protein-coupled receptors (GPCRs) act as molecular sensors central to all cellular and physiological systems complexity raises further fundamental questions and challenges in the study of GPCR action in multiple systems

focused on the development and commercialization of novel medicines for patients with central nervous system

This work highlights an important interplay between the adenosinergic and dopaminergic systems and suggests

multiforme (GBM), a type of the most lethal brain tumor, has remained a formidable challenge in terms of its treatment the normal neural and the GBM microenvironments, and discuss potential targeted drugs used for GBM treatment

1 receptor interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system

explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system

Although hypothetical, the reconstruction of the rod phototransduction system highlights the potential

Although such pheromone/receptor systems are likely to function in both mate choice and prezygotic isolation might reflect the significantly distinct stringency/flexibility of their respective pheromone/receptor systems

high-resolution techniques to investigate peptidergic transmission and expression throughout the brain in model systems

focused on the development and commercialization of novel medicines for patients with central nervous system

small molecule drugs known as allosteric modulators is being explored for treating central nervous system