kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Furthermore, expression of GPR30 in MCF7 cells constitutively and PDZ-dependently inhibits β1AR-mediated These results argue that GPR30 and β1AR form a PDZ-independent complex in MCF7 cells through which GPR30 adrenergic receptor Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell Organoid culture was used to assess the stemness and self-renewal capacity of alveolar epithelial type II cells in macrophages and decreased apoptosis in epithelial cells. a protective role in ALI not only in early inflammatory responses but also in endogenous lung stem cell Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal

Oncology and Immunology Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells disease (IBD) is characterized by dysbiosis of the gut microbiota and dysfunction of intestinal stem cells Using an engineered tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific adrenergic receptor Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative antagonists Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1 acid (5-oxo-ETE), leads to the formation of filopodia-like elongated projections connecting adjacent cells Kazanietz Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune response B cell A single-cell analysis was used to assess GNAI3 expression in GBM. Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Maria Waldhoer on the web LinkedIn T witter Pubmed Dr. GPCR About Dr. JoAnn Trejo "Dr. Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells GPCR, GprC, at the plasma membrane and together with the G-protein alpha subunit GasA, reprograms the cell Reinhard Fischer Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Experiments were then conducted using these cells which were divided into four groups of negative control periodontitis group (0.132±0.006) increased compared with that in periodontally healthy group (0.036±0.019) (t= Shang , S H Ge Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Randall T. Angers was named Director of the Donnelly Centre of Cellular and Biomolecular Research at the University

Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to RNA-seq analysis, 3D growth, in situ- and immunofluorescence analyses, and cell viability- and motility Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells Single cell in situ analysis of MCF-7 cells revealed that several GPR81-regulated genes were upregulated in the same cell clusters.

Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

histone deacetylase (HDAC) activities, protein modifications, signaling pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune cells. normal homeostasis and influencing tumor progression highlights the potential of targeting SCFA-mediated cellular Shan Li, Yixin Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu Tags acetate , butyrate , cancer , cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News GPCR Jobs Call

receptor proteins are proficient in sensing external signals and initiating downstream pathways to control cell GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis-a form of cell , Boyi Gan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Low extracellular pH confers radioresistant tumors to glial cells. inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway: ferroptosis Next, A GPI-anchored pH reporter, pHluorin2, was stably expressed in U87 glioblastoma cells to probe Cell survival assays, via nuclei counting and cell titer glo, were used to demonstrate sensitivity to To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq.

Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune cells Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently fatty acids Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell However, the role of β2-AR in oral cancer is not well identified. significance in relation with the clinicopathological features and overall survival of oral squamous cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts and which cells Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. cells.

S2 cells. Furthermore, treatment of S2 cells with GBP2 enhanced GBP1 expression levels, but GBP1 did not affect GBP2-induced enhancement of GBP1 expression was not observed in Mthl10 knockdown cells. Enhancement of GBP2 expression was observed in both Drosophila larvae and S2 cells under heat stress Finally, Ca2+ mobilization assay in GCaMP3-expressing S2 cells demonstrated that GBP2 mobilizes Ca2+

Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and cells Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors , Therapeutic targeting , Tumor cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Experimental design: We performed targeted sequencing, high-throughput drug screening, and single-cell genomic profiling on leukemia cell samples derived from patients with AML. understand the co-occurring mutation patterns and further investigated the mutation profiles in the single cells The application of single-cell genomic sequencing unveiled the co-occurrence of variants at the individual cell level, highlighting the presence of distinct subclones within patients with AML.

and hypoxia on migration, proliferation, invasion, and signaling in 2D and 3D models of breast cancer cell Antagonizing NPY1R and/or NPY5R in hypoxia compared to normoxia more greatly reduced MAPK signaling, cell proliferation, cell migration and invasion, and spheroid growth and invasion. The estrogen receptor positive MCF7 cells were significantly less invasive in 3D spheres when NPY5R was There were some discrepancies in the responses of each cell line to the isoform-specific antagonists

Depletion of GPR37 significantly reduced CRC tumor cell growth both in vitro and in vivo. Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 SCD1 , p38 Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type

transmitting signals inside the body, which is necessary for controlling the life activities of all cells , including tumor cells [1]. ATP functions as a mighty damage-linked molecular pattern when released outside the cell, accumulating protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune cell microenvironment (TME) Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

protein-coupled receptors (GPCRs), enhancing proliferation, adhesion, and migration in many types of cancer cells Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell In these cells, the mitogenic activity of LPA is mediated by LPA Receptor 1 (LPAR1), a GPCR. of CCN proteins by LPA, and by the related lipid mediator sphingosine-1-phosphate (S1P), in various cellular In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation

Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy . Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR