Search Results
103 items found for "Timo De Groof"
- Drug Discovery Picks Up the Pace, Stays on Target
January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time.
- New Resources in GPCRdb
This time, the GPCRdb team ( Dr. David Gloriam , Dr.
- From DNA day to GPCR genomics
conformational changes that occur during G-protein activation by the β2-adrenergic receptor, using a time-resolved Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv : the preprint server for biology, 2023.03.20.533387
- Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
We then mapped the 394 GPCR X-ray structures available at the time of the analysis (September 2020).
- 📰 GPCR Weekly News, March 11 to 17, 2024
M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, Georgios Skiniotis, et al. for their research on Time-resolved transport of nascent G protein-coupled receptors Structural and Molecular Insights into GPCR Function Time-resolved
- Propranolol: A “Pick and Roll” Team Player in Benign Tumors and Cancer Therapies
In 2008 (and for the first time in the clinic), the therapeutic benefits of the β-adrenergic receptor
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
The development of molecular tools to study GPCR trafficking in real-time opens new avenues for understanding
- 📰 GPCR Weekly News, November 13 to 19, 2023
For those who joined any of our symposium sessions, we kindly request a moment of your time to fill out – our premium members have continuous access to revisit and watch the archived presentations at any time
- A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New..
Here, we show for the first time that MRP3 expression is induced under hypoxia through the A2B adenosine
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs.
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
Topics: New cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll But act fast – this offer is only available for a limited time. Not a premium member yet?
- 📰 GPCR Weekly News, October 30 to November 4, 2023
Hannes Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan primary cultures of osteoblasts and osteoclasts Development of Fluorescent AF64394 Analogues Enables Real-Time
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
This timely meeting will not only provide an inclusive forum for communication, but also a platform for
- Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and ...
expression patterns of these 98 genes in various larval tissues were evaluated using quantitative real-time
- GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024
Delve into new cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll Premium members can enjoy a 25% OFF early bird discount , but hurry - it's only available for a limited time
- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB)) were analyzed at different time
- 📰 GPCR Weekly News, June 10 to 16, 2024
cardiac drug development GPCRs in Neuroscience Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
internalize both receptors whereas pasireotide promoted robust receptor internalization at shorter times
- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
Quantitative real-time probe-based polymerase chain reaction (qRT-PCR) assays are deployed in order to
- Enhancing GPCR Research Outreach | Dr GPCR University early-bird registration ends soon!
cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time
- TM5-TM6: structural switches that modulate the coupling of serotonin receptors to Gs or Gi
Likewise, in this work the authors identify for the first time the specific amino acids that modulate
- All Aboard the GPCR Express: Your Weekly Update is here! Oct 14-20, 2024
Understanding real-time kinetics to predict activity and in vivo target coverage.
- 📰 GPCR Weekly News, July 17 to July 23, 2023
Premium members can always go back and watch the recorded talks at any time.
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
October 31, November 7 - 14 -21, and December 5, 2024 (five sessions) Topics: New cellular assays, real-time
- 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!
cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time
- Dr. GPCR University registration is now open! Secure your spot now!
Essentials for effective GPCR discovery Discover: Advanced cellular assays for GPCR ligand behavior Real-time
- 📰 GPCR Weekly News, April 3 to 9, 2023
Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning.