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develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range

Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm We are bursting with pride in sharing it with you, and we sincerely want to thank you for your support , 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII

recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range

candidate into clinical trials "HTL0039732 is a novel EP4 antagonist with potential to treat a wide range

"G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including

August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range

G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological

ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range

Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging

GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,

Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of

2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

Modern drug development approaches include a range of techniques leveraging structural biology, immunology

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range

diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges

We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range

Nevertheless, the GloSensor™ cAMP assay can be applied to analyze signaling by a wide range of GPCRs

Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with desensitization), the same drug acting on the same receptor in the same cellular context can produce a range

Coupled with their ability to respond to a highly diverse range of chemical stimuli, they represent the

Chemical communication controls a wide range of behaviors via conserved signaling networks.

Consequently, the dynamic range for IL-6 detection as an assay for β-alanine-mediated activation of MRGPRD

The subfamily-defining CC/CXC/CX3C/XC motif is located in the N-loop and forms two conserved disulfide activation will pave the way for significant advancements in the development of therapeutics for a wide range