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cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts based on strong rationales, we studied the capacity of LP2 to inhibit the growth of patient-derived xenografts demonstrated that LP2 at a subcutaneously injected dose as low as 0.2 µg/kg/day inhibited patient-derived xenografts

Hoyer , Andreas Glück , Martina Guggeis , Alexander Ossysek , Andre Küller , Derk Frank , Christoph Lange

identified physiological hormones of such under characterized ‘orphan’ receptors and functional probes for a range

On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206).

Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range

sites on the receptor C termini, which dictates functional outcomes of β-arrestin-mediated signaling, ranging

We further show that these self-generated gradients can sustain the long-range guidance of DCs, adapt

Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared

A 12-point immunoreactive scoring (IRS) range was used for interpretation of the staining results.

receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging

we developed a patient-based, boundary-driven computational fluid dynamics model to predict an upper range

Published date November 13, 2024 Abstract "G protein-coupled receptor (GPCR) signaling regulates a wide range

demonstrate its ability to promote cancer cell motility. " Authors Yu Jin Lee , Kyeong Jin Shin , Hyun-Jun Jang Jin-Sun Ryu , Chae Young Lee , Jong Hyuk Yoon , Jeong Kon Seo , Sabin Park , Semin Lee , A Reum Je , Yang

Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion

Sumit Bandekar on the web Araç Laboratory at UChicago X (Twitter) LinkedIn Unveiling the GPS Cleavage

gut microbiota act as ligands for specific human G protein-coupled receptors (GPCRs) and modulate a range

Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang

knock-in mouse, H381S Frank Kwarcinski Tethered Peptide Activation Mechanism of Adhesion GPCRs Peng Xiao Demet Araç on the web Araç Laboratory at UChicago X (Twitter) Heterogeneity of Tethered Agonist Signaling Bernadyn, Mariane Nascimento, Xinyi Lu, Pauline L. Pan, Michael Holinstat and Gregory G. Abstract Only available for AGPCR 24 Workshop Attendees About Peng Xiao "I joined Prof. Peng Xiao on the web ResearchGate < Previous Session Next Session >

Neutrophils lacking all four GRK family members show increased chemotactic migration responses to a wide range

Lange and Annie Mary Lyle Chair in Cardiovascular Research, and Professor of Pharmacology, Ophthalmology

Abhishek Kumar Singh on the web Uniklinikum Erlangen Google Scholar X (Twitter) Investigating The Role Affiliations "Department of Biochemistry & Molecular Biology, University of New Mexico Health Sciences Center Xue Restoration of ADGRB1 expression slowed tumor growth and improved survival in mice bearing MB xenografts

Quick recap Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and

identify novel pharmacological targets and contribute to the development of innovative treatments for a range

simulations and coarse-grain sampling approaches for membrane proteins in collaborations with Thomas Huber , Xavier

targeting specific receptors for various diseases, with Arthur sharing insights on Eli Lilly's compound, Xanomeline

targeting specific receptors for various diseases, with Arthur sharing insights on Eli Lilly's compound, Xanomeline

Authors Pengfei Yan, Xi Lin, Lijie Wu, Lu Xu, Fei Li, Junlin Liu, Fei Xu Source Contribute to the GPCR

Tatsuma Matsuda, Naoko Hashimoto, Akitoshi Nakayama, Kazuyuki Yamagata, Masataka Yokoyama, Yingbo Gong, Xiaoyan