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140 items found for "Yanbin Ke"
- Structural landscape of the Chemokine Receptor system
system providing an overview of the chemokine binding mode and activation mechanisms (Urvas, Lauri & Kellenberger
- 📰 GPCR Weekly News, June 12 to 18, 2023
Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation.
- 📰 GPCR Weekly News, May 29 to June 4, 2023
Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes.
- 📰 GPCR Weekly News, May 22 to 28, 2023
GPCRs in Neuroscience PACAP key interactions with PAC1, VPAC1, and VPAC2 identified by molecular dynamics A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes.
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
extensive experimental datasets and in vivo validation which does not always align with in vitro evidence (Kenakin
- 📰 GPCR Weekly News, April 24 to 30, 2023
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- VAMP2: a crucial player in the delivery of MOR to the synapse
membrane can be modified depending on the integrity of its bi-leucine sequence (which is considered a key
- 📰 GPCR Weekly News, March 13 to 19, 2023
We thrive to keep you up-to-date with everything happening in the world of GPCR.
- 📰 GPCR Weekly News, February 27 to March 5, 2023
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- Regulators of G-protein signaling: essential players in GPCR signaling
the G-protein heterotrimeric complex (α, β, and γ); it is at this point when the RGS proteins play a key pain, RGS4 in pain regulation is a topic of increasing interest because it has been identified as a key
- Glyco-sulfo hotspots in the chemokine receptor system
CCR5 sulfation has been also reported to play a key role in CCL3 and CCL5 binding (Bannert N et al. 2001
- 📰 GPCR Weekly News, February 6 to 12, 2023
Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- 📰 GPCR Weekly News, January 30 to February 5, 2023
Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- 📰 GPCR Weekly News, January 23 to 29, 2023
Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
In general, signaling occurs when agonists engage key microswitch structures located in the TM domain Secondly, because the activation mechanism of small protein GPCRs involves making key contacts with the use of all the potential binding contacts with the TM domain of the receptor, and by modifying these key
- 📰 GPCR Weekly News, January 16 to 22, 2023
Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- 📰 GPCR Weekly News - January 9 to 15, 2023
Keep up-to-date with the latest research and advancements in the field with our convenient, weekly news
- Odorant receptors – a bit of smell for drug discovery
homeostasis (Gelis L. et. al 2016) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte
- 📰 GPCR Weekly News - January 2 to 8, 2023
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- 📰 GPCR Weekly News
Heptares Enters R&D Agreements with the University of Oxford and KU Leuven to Identify and Validate Key
- Overview of adhesion GPCRs self-activation
From a structural perspective, the -4 position of αH5 was key for the selectivity of G-protein coupling
- Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery
Junke Liu et al. recently provided key insights into GPCR oligomerization and biased signalling, using
- Therapeutic validation of an orphan G protein‐coupled receptor
Orphan GPCRs have been shown to play key roles in various physiological functions, such as sensory perception In this study Marsango et al. address two key questions in GPR84 biology and pharmacology: 1. how GPR84
- Ode to GPCRs
1967, the Nobel Prize in Physiology or Medicine was awarded jointly to Ragnar Arthur Granit, Haldan Keffer The 1971 Nobel Prize in Physiology or Medicine went to Earl Wilbur Sutherland Jr for discovering the key Incidentally, phosphorylation is a key regulatory mechanism employed in the GPCR-mediated signal transduction awarded for work relevant to GPCR-mediated signaling was the 2012 Nobel Prize in Chemistry to Brian Kent Keffer Hartline - Biographical. https://www.nobelprize.org/prizes/medicine/1967/hartline/biographical
- Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling
November 2022 "Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of physiologies The structures reveal unique ligand-engaging mode, distinctive activation conformation, and key mechanisms A comparison of Gq, Gs, Gi, and G12 engagements with ADGRL3 reveals the key determinant of G-protein
- Emerging approaches for decoding neuropeptide transmission
Here we describe the current technological landscape in which the field is operating to decode key questions
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
Here, we review the key findings of GPCR in the cochlea and discuss the role of GPCR in the cochlea,
- Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
Together with functional data, the structures reveal the key factors that govern the recognition of CX3CL1