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146 items found for "Ye K"
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Functional assays demonstrated that RGS16 promoted the CRC progression, knockdown of RGS16 led to significantly
- Ep 142 with Dr Claudia Stäubert
Yamina expressed interest in learning more about this topic as she realized her lack of knowledge on steps, including researching review articles or articles to gain a higher understanding of what is known
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that direct cAMP/protein kinase-A We performed genetic epistasis between Gpr161 or Ankmy2 mutants, and Gli2/Gli3 knockouts, Gli3R knock-in and knockout of Smoothened, the hedgehog pathway transducer. We also tested the role of cilia-generated signaling using a Gpr161 ciliary localization knock-in mutant The cAMP signaling-competent non-ciliary Gpr161 knock-in recapitulated Gpr161 loss-of-function tissue
- Ep 118 with Dr. David Sykes
this period David has made a significant contribution to the understanding of agonist/ antagonist GPCR kinetic His current interests include the development of HTS fluorescence-based kinetic binding assays specifically designed to assess the kinetics of unlabelled compounds (and chemical fragments) and the use of purified
- Ep 150 with Dr GPCR Team
Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney She received her undergraduate degree in Biotechnology from KIIT University in India. Further down the track, he aims to apply this knowledge to develop novel chemical treatments for neuronal
- Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease
Toronto and has continued working on dopamine transmission and homeostasis and the role of several of key
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
be useful, but we hypothesized that mathematical modeling could be useful when there is incomplete knowledge Authors Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes
Although the mechanism of T2DM is not yet fully known, inflammation and insulin resistance play a central Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression.
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Authors Victoria H Wu , Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander
- Ep 65 with Dr. Sudarshan Rajagopal
Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue
- Ep 76 with Steve McCloskey
time at UC San Diego Steve worked directly with the founding Chair of the Nanoengineering Department, Ken
- Ep 70 with Dr. Stephen Ferguson
University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases
- Ep 75 with Vaithish Velazhahan
Vaithish obtained dual bachelor’s degrees with honors in Medical Biochemistry and Microbiology from Kansas
- Ep 145 with Dr John Janetzko
Daniel Kahne and Suzanne Walker studying the structure and function of the essential human enzyme, O-GlcNAc Brian Kobilka at Stanford University at the end of 2017 for postdoctoral work. Yamina emphasized that the content should be kept in a PG-13 context and be scientifically related to John's Chemistry Olympiad Journey John shared his experiences in high school, where he developed a keen He shared his experience working on a project involving receptor kinases and collaborating with other
- Ep 155 with Endocrine Metabolic GPCR Organizers
She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced
- Ep 151 with Dr GPCR Board
Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR
- Ep 148 with Dr Arthur Christopoulos
Two Ferns', the importance of maintaining team culture, and the potential health issues among well-known discussed the growth and development of the Monash Institute of Pharmaceutical Sciences, the importance of knowing
- Ep 154 with Dr Badr Sokrat
They also discussed the concept of serendipity in scientific research, illustrating with examples of Kathleen They highlighted the significance of collaboration and delegation in scientific research, noting that knowing
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
Authors Mithila Tennakoon , Waruna Thotamune , John L Payton , Ajith Karunarathne Tags HMG-CoA reductase
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
Conversely, we observed that GPR37 knockdown suppresses NSCLC cell invasion, migration, and proliferation Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC.
- Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
is modulated by extracellular vesicles (EVs) and vesicular mediators released by efferocytes is not known Neutralization and knockdown of prosaposin or blocking GRP37 abrogates the pro-resolution effects of Authors Purbasha Bhattacharya , Umesh Kumar Dhawan , Mohammed Tayab Hussain , Praveen Singh , Karran Kiran Bhagat , Aarushi Singhal , Shani Austin-Williams , Shantanu Sengupta , Manikandan Subramanian Tags
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
and methods: The viability and apoptosis of human DPSCs (hDPSCs) were determined using Cell Counting Kit were used to confirm the binding between miR-708-5p and circFKBP5 or G-protein-coupled receptor (GPCR)-kinase LPS induced miR-708-5p expression in hDPSCs, and knockdown of miR-708-5p protected against LPS-evoked
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
Authors Elric Zweck , Maximilian Karschnia , Daniel Scheiber , Harald Heidecke , Ralf Dechend , Carmen Barthuber , Sina Kaufmann , Malte Kelm , Michael Roden , Ralf Westenfeld , Julia Szendrödi , Fritz Boege
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
: RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming Soon About Kathleen Caron "Kathleen M. Keith Parker to elucidate the role of steroidogenesis in regulating sexual determination and adrenal Kathleen Caron on the web UNC-Chapel Hill Department of Cell Biology and Physiology UNC Lineberger Comprehensive
- G Protein-coupled Receptor-mediated Membrane Targeting of PLCγ2 is Essential for Neutrophil Chemotaxis
chemoattractants G protein-coupled receptors (GPCRs) activate β phospholipase C (PLCβ) while receptor tyrosine kinases
- Advanced data analysis for GPCR pharmacology
Module 4 - New dimensions of activity: Allosteric modulators and kinetics. Good to know: Classes will be live from Zoom on Thursdays from 10 am to 12:00 pm EST. Sam specializes in kinetic analysis of drug action and is known for applying binding and signaling kinetics Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors, from the University of Kent in the United Kingdom.
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
Notable pathways included "Cytoskeleton remodeling regulation of actin cytoskeleton organization by the kinase Authors Ahmad Raza , Meng-Chi Yen , Gangga Anuraga , Iram Shahzadi , Muhammad Waqar Mazhar , Hoang Dang Khoa Ta , Do Thi Minh Xuan , Sanskriti Dey , Sachin Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William