Regulation of the pro-inflammatory G protein-coupled receptor GPR84. GPCRs in Cardiology, Endocrinology, and Taste FFAR4 regulates cardiac oxylipin balance to promote inflammation Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory

β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory receptors (GPCRs) have emerged as key players in regulating (patho)physiological processes, including inflammation involvement of the human Mas-related G-protein coupled receptor D (MRGPRD) in the regulation of the inflammatory the observation that MRGPRD mediates the release of IL-6 in an in vitro system, hints at a role as an inflammatory

triggered by LPS treatment, suggesting a positive correlation between enhanced calcium transients and the inflammatory phenotype of astrocytes observed in the inflamed brain.

Pain may associate with inflamed tissue characterized by acidic pH.

impairment in two mouse models of Alzheimer's disease GPCRs in Oncology and Immunology Itaconate in host inflammation

and Immunology Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation

Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant Neuroimmune interplay during type 2 inflammation

Extracellular Signal-Regulated Kinase: A Regulator of Cell Growth, Inflammation, Chondrocyte and Bone

Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation

GPCR Activation and Signaling Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation

using molecular dynamic simulations Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory fibroblast-associated diseases Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation

Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation

and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation Collaboratives Program AIRSUPRA® (albuterol/budesonide) now available as the first and only FDA-approved anti-inflammatory

GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

the Treatment of Neurological Disease s Activation of GPR55 alleviates neuropathic pain and chronic inflammation

CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation.

Cardiology, Endocrinology, and Taste The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory Cumulus Oncology, to develop therapeutics targeting G protein-coupled receptors to treat cancer and inflammation

August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans." Read more at the source #DrGPCR #GPCR #IndustryNews

disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation

which work in a team with canonical chemokine receptor to drive regulated immunological responses and inflammatory Volpe et al. 2012); it dampens the inflammatory response when needed (C. A. H. In monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2, and CCR5 switch

GPCR Binders, Drugs, and more Modelling altered signalling of G-protein coupled receptors in inflamed

receptors (CKRs) belong to a subfamily of G-protein-coupled receptors (GPCRs) and play a crucial role in inflammation

CCR2 Antagonist The chemokine receptor CCR2 regulates the recruitment of monocytes to the sites of inflammation Since many inflammatory diseases are driven by inappropriate recruitment of monocytes into tissues, CCR2 has been described as the master controller of inflammatory pathology and is considered a valuable drug target for a number of inflammatory diseases including atherosclerosis, scleroderma, multiple sclerosis OB-004 showed powerful efficacy, achieving full blockade of monocyte recruitment in response to the inflammatory

Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 SPMs exert anti-inflammatory

Endocrinology, and Taste Cyclic adenosine monophosphate critically modulates cardiac GLP-1 receptor's anti-inflammatory

increases the risk of obesity Norton Cheng, JoAnn Trejo, et al. for their research on Ubiquitin-driven GPCR Inflammatory signaling durations and the structural determinants thereof Ubiquitin-driven G Protein-Coupled Receptor Inflammatory

downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory

Industry News Sosei Heptares Doses First Subject in Phase 1 Trial with HTL0033744, an EP4 Agonist for Inflammatory Regains Full Ownership from GSK of HTL0027477, a Clinic-ready, First-in-Class Oral GPR35 Agonist for Inflammatory