Neuroscience Spatiotemporal organization of prefrontal norepinephrine influences neuronal activity Transient cAMP

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Persistent cAMP Signaling by Internalized LH Receptors in Ovarian Follicles.

et al. 2021), that allow interaction with trimeric G proteins, which regulate second messengers like cAMP

symposium on GPCRs in Medicinal Chemistry Dates Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus

Orally bioavailable compound 47 with favorable agonist potency (Ca2+EC50 = 24 nM, cAMPi EC50 = 6.5 nM

The story behind how Dr.GPCR came to be, the people behind the process, the great anecdotes, and what

Vasculitis Adopted by European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP

When I came this morning to work this is how I found my desk.

While early evidence for the role of oligomerization in receptor signaling came from ensemble biochemical

A rational drug discovery campaign hinges on a deep understanding of how distinct molecules interact

processes of target receptor expression, purification and stabilization at the beginning of a discovery campaign The PROcisionXᵀᴹ platform (summarized in Figure 2) can be used to complete a discovery campaign within Figure 3: In a single discovery campaign (CCR5 is shown as an example), Orion’s PROcisionXᵀᴹ platform

study its function in both disease and physiological settings will likely potentiate drug discovery campaigns