GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Senior Researcher in Structural Biology Fellow Research Laboratory Specialist Associate Postdoctoral Scientist Principal Investigator, In Vitro Biology

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expression data in healthy tissues from the Genotype-Tissue Expression (GTEx) database with data from cancer samples in The Cancer Genome Atlas (TCGA) through the Gene Expression Profiling Interactive Analysis (GEPIA) tool, it is evident that β-arrestin expression is dysregulated in many cancer types. In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains Innovative structural biology techniques, pharmacological methods, state-of-the-art biosensors, supplementary

endocrinology and metabolism Reviews, GPCRs, and more Butyrate as a promising therapeutic target in cancer Revolutionary Impact of Cryo-EM on GPCR Research GPCR Events, Meetings, and Webinars March 13 - 15 | Biologics Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics Operations - Single-molecule Imaging Center Scientific Assistant Postdoctoral Fellowship- Mechanistic Biology

Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer RGS proteins and their roles in cancer: friend or foe?. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

scientists and researchers and gain valuable insights into the latest developments in adhesion GPCR biology approach for combating multi-drug resistant Staphylococcus aureus Isolation, Structure Elucidation, and Biological Reviews, GPCRs, and more Lessons from the physiological role of guanosine in neurodegeneration and cancer September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics

October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical for colon cancer EGFR/erbB is among the most prominent cancer targets. Overall, our studies are expected to allocate new targets for cancer therapy. Pc(4-4) may become a promising candidate for future therapeutic cancer treatment."

July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Scientist I Cell Biology Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist mouse neutrophils Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking The Effect of Cancer-Associated Mutations

GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach. Industry News Exscientia Initiates Prospective Observational Study in Ovarian Cancer. Undrugged GPCR Target in Four Months Cumulus Oncology and Leadxpro collaborate on small molecules targeting cancer-focused

macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer It has begun to play important roles in drug development for complex diseases such as cancer, including triple-negative breast cancer (TNBC). incorporated the dynamics of TAMs into our previously published QSP model to investigate their impact on cancer

For instance, aberrant endosomal signaling by GPCRs has been linked to disorders such as cancer, neurodegenerative The Journal of membrane biology, 254(3), 259–271. https://doi.org/10.1007/s00232-020-00158-7 Gonçalves-Monteiro Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy Nature chemical biology, 13(7), 799–806. https://doi.org/10.1038/nchembio.2389 Godbole, A., Lyga, S., GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic

adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed

passion and connect with your amazing peers to dive into the cutting-edge advancements in adhesion GPCR biology Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Webinars September 30 - October 3, 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist studies to identify potential agonists of orphan receptor GPR78 targeting CNS disorders Predicting biological

Nicholas Kapolka , Geoffrey Taghon , and Daniel Isom  for their research on Advances in yeast synthetic biology for human GPCR biology and pharmacology Dr. from October 23-25, 2024, to connect with fellow scientists and explore the latest in adhesion GPCR biology protein-coupled receptor (GPCR) gene variants and human genetic disease Advances in yeast synthetic biology for human G protein-coupled receptor biology and pharmacology Industry News Muscarinic drugs breathe

Adam W Smith for their research on β2-adrenergic receptor associates with CXCR4 multimers in human cancer GPCRs in Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cancer Therapeutics Announces Publication in PNAS Using Cutting Edge Spectroscopy to Detect GPCR Heteromers on Live Cancer Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics

Vladimir Katanaev and colleagues identified compromised GPCR signaling in cancer cells using improved MRGPRX1 Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer activation PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer Therapeutics' latest science paper was published by the American College of Clinical Pharmacology Sosei and Cancer

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mechanism of GPCR spatial organization at the plasma membrane, featured on the cover of Nature Chemical Biology founded by Cumulus Oncology, to develop therapeutics targeting G protein-coupled receptors to treat cancer Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellowship- Mechanistic Biology NEW Research Scientist Post-Doc position Lead Researcher Senior Researcher in Structural Biology Post-Doctoral

Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1 Esophageal and gastric cancer incidence trends in Golestan, Iran: An age-period-cohort analysis 2004 Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells. Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential

4256, a Highly Potent and Selective Inhibitor of GPR65, in Presentation at American Association for Cancer Events, Meetings, and Webinars NEW FREE 7th ERNEST GPCR zoominar (April 20, 2023) SLAS 2023 Building Biology Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

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GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers (March 30, 2023) SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

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Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression SLAS 2023 Building Biology in 3D Symposium. Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.