< GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in GPCRs) are the most frequently exploited drug target family, moreover they are often found mutated in cancer We explored cancer-related mutation patterns in all GPCR classes combined and individually. families, but also discovered novel GPCRs which had not been linked to cancer before such as the P2Y Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G Proteins and GPCRs in Cancer Department of Pharmacology, School of Medicine, and Associate Director for Basic Science at the Moores Cancer treatments, and to identify novel multimodal strategies to enhance the response to cancer immunotherapies Silvio Gutkind on the web Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications Pubmed LinkedIn Twitter UCSD Moores Cancer Center Dr.

University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure at the cell Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA 5 O'Neal Comprehensive Cancer Van Meir pursued postdoctoral work at the Ludwig Institute for Cancer Research in San Diego and joined Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic translate these novel agents to testing in clinical trials with the hope to develop novel medicines for cancer To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines

combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis Published date November 3, 2023 Abstract " Purpose : Peripheral T-cell lymphoma (PTCL) is an aggressive disease with a poor prognosis. Brentuximab vedotin (BV), an anti-CD30 monoclonal antibody linked to a microtubule-disrupting agent, HH cells, originating from an aggressive cutaneous T-cell lymphoma, were used as an experimental model

types (neutrophils, T cells, B cells and dendritic cells) and systematically addressed the functional consequences on GPCR-controlled cell migration and tissue localization. Combined depletion of GRK2 and GRK6 in T cells and B cells shows distinct functional outcomes for (a) one GPCR type in different cell types, and (b) different GPCRs in one cell type. ; GRK; T cells; dendritic cells; immune cell trafficking; leukocytes; neutrophils.

Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract "Immune cells Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and cancer Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory itaconate Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers , including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic cancer structure-activity relationships and clinical significance of CXCR2 antagonists in inflammatory diseases and cancers Authors Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer

< GPCR News < GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML cell lines with diverse genetic profiles. We further showed that the combination of 8GL and an mTOR inhibitor synergistically elicited AML cell

Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative We examined the prenylation of carboxy-terminus (Ct) mutated Gγ in cells exposed to Fluvastatin and prenyl monitored the subcellular localization of fluorescently tagged Gγ subunits and their mutants using live-cell mechanism allowing for statins to differentially perturb heterotrimeric G protein signaling in cells repurposing statins as Ras oncogene inhibitors and the failure of using prenyltransferase inhibitors in cancer

Immunology Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer While the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. serve as a powerful medicament in STICs and ovarian cancer. receptors (PARs) Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer Among the five somatostatin receptors, SST2 and SST3 are associated with apoptosis and cell cycle arrest SST2 and SST3 reemerged in metastases suggesting conserved receptors genetic potential during tumor life Michel Afargan Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss, suggesting a possible link. with implications for immunity against viral diseases and vaccines inducing CD8 TRM cells."

progression in MCF-7 cells Published date March 1, 2024 Abstract "Vasoactive intestinal peptide (VIP In this study, we examined the role of VIPR2 in cell cycle progression. in MCF-7 cells. The percentage of cells in the S-M phase was decreased in MCF-7 cells treated with KS-133. In MCF-7 cells stably-expressing VIPR2, KS-133 decreased PI3K activity and cAMP levels.

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Cell lines expressing EBI2 were established by transduction with HIV vectors. The amount of HIV reverse transcripts was similar in cells expressing or not EBI2. Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency by decreased creatinine clearance and urea excretion and a decreased presence of regulatory T (Treg) cells increased activation of the immune system and a higher production of pro-inflammatory cytokines by T cells kidney stones Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

News < GPCRs in Oncology and Immunology Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy Published date September 26, 2023 Abstract "Infections are an important complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy and risks may differ between the early and late periods. Respiratory infections predominate after BCMA CAR T-cell therapy, particularly after day 100.

GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells We have used the method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets. On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206).

< GPCR News < GPCRs in Oncology and Immunology Colorectal cancer incidence trends in Golestan, Iran: the effects of factors including age, birth year (cohort) and diagnosis year (period) on colorectal cancer Methods: We obtained data on incidence cases of CRC from the Golestan Population-based Cancer Registry (EAPC) with 95 % confidence intervals (95 % CI) fitted age-period-cohort (APC) models to assess non-linear Weiderpass , Gholamreza Roshandel , Freddie Bray , Reza Malekzadeh Tags Age-Period-Cohort model , Colorectal Cancer

News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells High GPR141 messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell myelin oligodendrocyte glycoprotein 35-55-specific T cells. , experimental autoimmune encephalomyelitis , monocytes , myeloid cells .

This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy . Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K These findings show that 3DMTR identified intolerant residues that overlap with cancer-linked mutations STATEMENT: Human genetic variant/mutation information has expanded rapidly in recent years, including cancer-linked tolerance ratio (3DMTR) to define regions of genetic intolerance in RGS proteins and prioritize which cancer-linked

< GPCR News < GPCRs in Oncology and Immunology Esophageal and gastric cancer incidence trends in Golestan June 29, 2023 Abstract "Golestan province in the northeast of Iran is part of the Asian esophageal cancer belt and is known as a high-risk area for esophageal (EC) and gastric cancers (GC). on incident cases of EC and GC during 2004 to 2018 were obtained from the Golestan Population-based Cancer Malekzadeh Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling Enhanced S1P signaling promoted glioblastoma cell proliferation and survival by activating the kinases AKT and CHK1 and the transcriptional regulators cMYC and STAT3 and by increasing the abundance of cancerous US28 also activated the S1P signaling axis in HCMV-infected cells. Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den

Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation, and cancer acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells human TIPE family members, TNFAIP8 and TIPE2 were essential for directed migration of human CD4+ T cells T Cells deficient in both of these proteins completely lost their directionality. bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3) to spatiotemporally control immune cell Collectively, our work describes a new mechanistic paradigm for how human T cells integrate GPCR and

Role Of GPR97/ADGRG3 In Neutrophil Biology Tyler Bernadyn Next Generation MBD2 inhibitors for Brain Cancer Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer El Merahbi Rabih, Herzig Stephan , Georgiadi A , Helmholtz Center Munich, Institute of Diabetes and Cancer and cell-matrix interactions. Renal Adgrf5 is restricted to two distinct populations of cells: AICs and endothelial cells (ECs).

Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules for gut immune cells by the gut bacterial metabolite pyruvate, is specifically expressed on type 1 conventional dendritic cells Using human induced pluripotent stem cell-derived cDC1s and a monolayer human gut organoid coculture Authors Tags Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call