Published date October 23, 2023 Abstract Glioblastoma multiforme (GBM) is one of the most aggressive cancers We used The Cancer Genome Atlas (TCGA) GBM genomic dataset to identify differentially expressed genes remodeling regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases" and "Immune

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Genetic variants in RGS proteins are associated with many diseases, including cancers, although the impact Intolerant and tolerant-control residues that overlap with pathogenic cancer mutations reported in the COSMIC cancer database were selected to define the functional phenotype. Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K

< GPCR News < GPCRs in Oncology and Immunology Colorectal cancer incidence trends in Golestan, Iran: the effects of factors including age, birth year (cohort) and diagnosis year (period) on colorectal cancer Methods: We obtained data on incidence cases of CRC from the Golestan Population-based Cancer Registry Weiderpass , Gholamreza Roshandel , Freddie Bray , Reza Malekzadeh Tags Age-Period-Cohort model , Colorectal Cancer

< GPCR News < GPCRs in Oncology and Immunology Esophageal and gastric cancer incidence trends in Golestan June 29, 2023 Abstract "Golestan province in the northeast of Iran is part of the Asian esophageal cancer belt and is known as a high-risk area for esophageal (EC) and gastric cancers (GC). on incident cases of EC and GC during 2004 to 2018 were obtained from the Golestan Population-based Cancer

< GPCR News < GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Published date September 21, 2024 Abstract "Colorectal cancer Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression

GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune

GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21, 2024 Abstract "Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic modulators play essential role within regulating downstream signaling of GPCR receptors, with function in cancers

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Epithelial ovarian cancer (EOC) is a leading cause of death among gynecological malignancies. Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion , MMP-9 , NPFFR2 , Neuropeptide FF , Ovarian cancer

and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer prior study, we reported the synergistic cytotoxic effects of gemcitabine and trabectedin on pancreatic cancer analysis was performed, and a system pharmacodynamics model (SPD) was developed to capture pancreatic cancer Straubinger , William J Jusko Tags Systems Pharmacodynamic , drug combination , gemcitabine , pancreatic cancer

Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer adenocarcinoma (PDAC) remains an aggressive disease that is expected to become the second cause of cancer siRNA-mediated knockdown of YES1, and transfection of epitogue-tagged YAP mutants in PANC-1 and Mia PaCa-2 cancer

protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health concern and represents the most common cause of cancer-related death worldwide. protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell lung cancer

guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Stephen Serafin , Tobias Schmidt , Björn Olde , Kathleen M Caron , L M Fredrik Leeb-Lundberg Tags Breast cancer

SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated immune this study assessed the differential regulation of the gene network associated with neuroendocrine immunity

GPCRs in Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1

hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses immune Lymphocytes enriched from Gpr141 -/- mice immunized with myelin oligodendrocyte glycoprotein 35-55 produced These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling

The intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules for gut immune (GPCRs) sense metabolites and can act as key mediators that translate gut luminal signals into host immune Our results highlight the role of GPCRs in tuning the human gut immune system according to local metabolic

A large component of his work is centered around dysregulated signaling in cancer and the development of novel mechanism-based cancer therapies. Silvio Gutkind on the web Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications More J Silvio Gutkind on LinkedIn Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.

Oncology and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer

dendritic cells (DCs) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes and skin immunity Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function

In this episode, Silvio discusses G protein signaling in the context of cancer, immunotherapies, and J Silvio Gutkind on LinkedIn Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications Gutkind Lab on Pubmed Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.

treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune

RGS5 expression in the triple-negative (TNBCs) and non-triple-negative breast cancers (Non-TNBCs) was The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs In contrast, in the context of breast cancer tissues, the role of RGS5 was completely disrupted. RGS5 expression was increased in the triple-negative breast cancer (TNBC) tissues and in the tumor blood Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer

CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express Moreover, our findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer

He currently is focusing on the development of nanobody-based immuno tracers as part of the IMI/EFPIA project entitled "Immune Image".

University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford

signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed in many solid breast cancers , and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays.

rationales, we studied the capacity of LP2 to inhibit the growth of patient-derived xenografts of colorectal cancer on an untreated tissue array demonstrated that the AT 2 R expression is reduced in human colorectal cancer specificity, safety and stability, warrant further evaluation of LP2's inhibitory potential of colorectal cancer . " Authors P Namsolleck , L de Vries , G N Moll Tags AT(2)R , Agonist , Angiotensin , Cancer , GPCR