< GPCR News < GPCRs in Oncology and Immunology miR-19a may function as a biomarker of oral squamous cell Using a transcriptomic analysis of over 37,000 nuclei, we identified twelve distinct clusters of cells corresponding to temperature-sensing arista neurons, humidity-sensing sacculus neurons, and support cells We found that each cell type could be characterized by a unique expression profile of ion channels, GPCR signaling molecules, synaptic vesicle cycle proteins, and cell adhesion molecules.

< GPCR News < GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy Authors listed Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative antagonists Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell Organoid culture was used to assess the stemness and self-renewal capacity of alveolar epithelial type II cells in macrophages and decreased apoptosis in epithelial cells. a protective role in ALI not only in early inflammatory responses but also in endogenous lung stem cell Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes

of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells GPCR, GprC, at the plasma membrane and together with the G-protein alpha subunit GasA, reprograms the cell Reinhard Fischer Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells Davide’s work has been published in prestigious scientific journals such as Nature, Cell, New England Journal of Medicine, Journal of Clinical Investigation, PLoS Biology, PNAS, Nature Communications and

Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells Using a model of human adrenocortical cancer cells, here we established that activation of the GPCR OXER1 acid (5-oxo-ETE), leads to the formation of filopodia-like elongated projections connecting adjacent cells Kazanietz Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Besides, the "ssGSEA" algorithm was conducted to estimate immune cells infiltration abundance, with ' differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand receptor , CD8 T cell, eosinophils, macrophages, neutrophils, NK CD56dim cells, NK cells, plasmacytoid DCs (pDCs ), T helper cells and T effector memory (Tem) cells. The possible biological mechanisms of GPR37 provide novel insights into the clinical diagnosis and treatment

, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila S2 cells Furthermore, treatment of S2 cells with GBP2 enhanced GBP1 expression levels, but GBP1 did not affect GBP2-induced enhancement of GBP1 expression was not observed in Mthl10 knockdown cells. Enhancement of GBP2 expression was observed in both Drosophila larvae and S2 cells under heat stress Finally, Ca2+ mobilization assay in GCaMP3-expressing S2 cells demonstrated that GBP2 mobilizes Ca2+

adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles in GBM biology We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types CD97-lacking cells. His group has been particularly interested in the role adhesion GPCRs play in glioblastoma biology and a productive, independent scientific research career in adhesion G protein-coupled receptor (aGPCR) biology

He also worked on creating novel methods for systems biology using temporal logic specifications while Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. They highlighted that while there was a time when biology lagged due to the lack of appropriate tools and relevance of mathematical models in systems biology and pharmacology.

The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy . Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Furthermore, expression of GPR30 in MCF7 cells constitutively and PDZ-dependently inhibits β1AR-mediated These results argue that GPR30 and β1AR form a PDZ-independent complex in MCF7 cells through which GPR30 adrenergic receptor Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

Transcript Variants in Mouse Kidney Hailey Steichen Elucidating The Role Of GPR97/ADGRG3 In Neutrophil Biology Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany 3 Department of Developmental Biology He has received his BSc and MS degree from the Department of Biochemistry and Molecular Biology, University Authors & Affiliations "Department of Biochemistry & Molecular Biology, University of New Mexico Health I received my MS in Applied Toxicology from the University of Washington, and my BA in Biology from Vassar

., PNAS, 2014) in breast cancer pathogenesis, using mouse models, three-dimensional cell culture and interest in science originated from a young age and his desire to gain more knowledge about cancer biology They also shared their personal experiences and interest in the field of biology. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its cancer cells, and suggested a therapeutic index for a drug called JTE-6.7.

Paul Insel was at the FASEB experimental biology meeting in Atlantic City. in Physiology or Medicine for their discovery of G-proteins and their role in signal transduction in cells hooked and has since studied receptor function in human physiology, receptor molecular pharmacology in cells

of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine CXCL10(1-77) using surface plasmon resonance for glycosaminoglycan (GAG) binding affinity, assays for cell migration, second messenger signaling downstream of CXCR3, and flow cytometry of CHO cells and primary human T lymphocytes and endothelial cells.

Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

Immunology Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell However, the role of β2-AR in oral cancer is not well identified. significance in relation with the clinicopathological features and overall survival of oral squamous cell Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to RNA-seq analysis, 3D growth, in situ- and immunofluorescence analyses, and cell viability- and motility Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells Single cell in situ analysis of MCF-7 cells revealed that several GPR81-regulated genes were upregulated in the same cell clusters.

GPCR Ecosystem About Monserrat Avila Zozaya I am a cell biologist interested in studying GPCRs, especially developed expertise over the past two decades studying structure/function relationships of GPCRs using live-cell Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

Low extracellular pH confers radioresistant tumors to glial cells. inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway: ferroptosis Next, A GPI-anchored pH reporter, pHluorin2, was stably expressed in U87 glioblastoma cells to probe Cell survival assays, via nuclei counting and cell titer glo, were used to demonstrate sensitivity to To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq.

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed Notably, single-cell RNA sequencing of the lung shows a drop in TRM cells in species with CXCR6 loss, The concurrent loss of ITGAE, CXCL16, and CXCR6 in chickens may have altered CD8 TRM cell abundance, with implications for immunity against viral diseases and vaccines inducing CD8 TRM cells."

Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the me to shape a swiss start-up company from a scientifc idea to a thriving Biotech focusing on Systems Biology Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells

2024 Abstract "Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells as induce T helper 17 (Th17) cell differentiation leading to elevated production of interleukin 17 ( In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected abnormal proliferation as well as Th17 cells differentiation. Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function

Sri Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology He is passionate about developing more rational ways to understand and engineer biology. empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical biology , synthetic biology, and functional genomics. He is a Searle Scholar (2015), NIH New Innovator (2014), and received his ScD in Biological Engineering